Document Detail

Cardioprotection with volatile anesthetics in cardiac surgery.
MedLine Citation:
PMID:  18515682     Owner:  NLM     Status:  MEDLINE    
Myocardial ischemia during the perioperative period is a major cause of morbidity and mortality after surgery. Experimental data indicate that clinical concentrations of volatile anesthetics protect the myocardium from ischemia and reperfusion injury, as shown by decreased infarct size and more rapid postoperative recovery of contractile function. These anesthetics may also mediate protective effects in other organs, such as the brain and kidney. A number of recent reports have indicated that these experimentally observed protective effects might also be present in the clinical setting. Implementation of such cardioprotection during surgery may provide an additional tool in the treatment and prevention of ischemic cardiac dysfunction in the perioperative period. This review discusses the clinical studies that have focused on the potential cardioprotective effects of volatile anesthetic agents.
Suraphong Lorsomradee; Stefanie Cromheecke; Sratwadee Lorsomradee; Stefan G De Hert
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Asian cardiovascular & thoracic annals     Volume:  16     ISSN:  1816-5370     ISO Abbreviation:  Asian Cardiovasc Thorac Ann     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503417     Medline TA:  Asian Cardiovasc Thorac Ann     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  256-64     Citation Subset:  IM    
Department of Anesthesiology, Academic Medical Center, University of Amsterdam, The Netherlands.
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MeSH Terms
Anesthetics, Inhalation / administration & dosage,  therapeutic use*
Cardiac Surgical Procedures / adverse effects*
Ischemic Preconditioning, Myocardial
Myocardial Ischemia / etiology*,  prevention & control*
Reg. No./Substance:
0/Anesthetics, Inhalation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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