Document Detail


Cardioprotection with palm oil tocotrienols: comparision of different isomers.
MedLine Citation:
PMID:  18083895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A recent study from our laboratory indicated the cardioprotective ability of the tocotrienol-rich fraction (TRF) from red palm oil. The present study compared cardioprotective abilities of different isomers of tocotrienol against TRF as recently tocotrienol has been found to function as a potent neuroprotective agent against stroke. Rats were randomly assigned to one of the following groups: animals were given, by gavage, either 0.35%, 1%, or 3.5% TRF for two different periods of time (2 or 4 wk) or 0.03, 0.3, and 3 mg/kg body wt of one of the isomers of tocotrienol (alpha, gamma, or delta) for 4 wk; control animals were given, by gavage, vehicle only. After 2 or 4 wk, rats were killed, and their hearts were then subjected to 30 min of global ischemia followed by 2 h of reperfusion. Dose-response and time-response experiments revealed that the optimal concentration for TRF was 3.5% TRF and 0.3 mg/kg body wt of tocotrienol given for 4 wk. TRF as well as all the isomers of tocotrienol used in our study provided cardioprotection, as evidenced by their ability to improve postischemic ventricular function and reduce myocardial infarct size. The gamma-isoform of tocotrienol was the most cardioprotective of all the isomers followed by the alpha- and delta-isoforms. The molecular mechanisms of cardioprotection afforded by tocotrienol isoforms were probed by evaluating their respective abilities to stabilize the proteasome, allowing it to maintain a balance between prodeath and prosurvival signals. Our results demonstrated that tocotrienol isoforms reduced c-Src but increased the phosphorylation of Akt, thus generating a survival signal.
Authors:
Samarjit Das; Istvan Lekli; Manika Das; Gergo Szabo; Judit Varadi; Bela Juhasz; Istvan Bak; Kalanithi Nesaretam; Arpad Tosaki; Saul R Powell; Dipak K Das
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication     Date:  2007-12-14
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  294     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-12     Completed Date:  2008-03-31     Revised Date:  2012-09-12    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H970-8     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / chemistry,  pharmacology*
Apoptosis / drug effects
Blotting, Western
Cardiotonic Agents*
Dose-Response Relationship, Drug
Genes, src / genetics,  physiology
Heart / drug effects
Heart Function Tests
Isomerism
Male
Malondialdehyde / metabolism
Myocardial Infarction / pathology
Myocardium / metabolism
Oncogene Protein v-akt / genetics,  metabolism
Plant Oils / chemistry*
Proteasome Endopeptidase Complex / drug effects
Rats
Rats, Sprague-Dawley
Tocotrienols / chemistry,  pharmacology*
Grant Support
ID/Acronym/Agency:
HL-068936/HL/NHLBI NIH HHS; HL-22559/HL/NHLBI NIH HHS; HL-33889/HL/NHLBI NIH HHS; HL-69910/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Cardiotonic Agents; 0/Plant Oils; 0/Tocotrienols; 542-78-9/Malondialdehyde; 8002-75-3/palm oil; EC 2.7.11.1/Oncogene Protein v-akt; EC 3.4.25.1/Proteasome Endopeptidase Complex
Comments/Corrections
Retraction In:
Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2449   [PMID:  22833919 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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