Document Detail


Cardioprotection with adenosine: 'a riddle wrapped in a mystery'.
MedLine Citation:
PMID:  15895103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: 'I cannot forecast to you the action of adenosine. It is a riddle wrapped in a mystery inside an enigma'. That is, although it is well-established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion-induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size.
Authors:
Karin Przyklenk; Peter Whittaker
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  145     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2005-10-28     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  699-700     Citation Subset:  IM    
Affiliation:
Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. Karin.Przyklenk@umassmed.edu
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MeSH Terms
Descriptor/Qualifier:
Adenosine / pharmacology*
Animals
Cardiotonic Agents / pharmacology*
Myocardial Infarction / prevention & control*
Myocardial Reperfusion Injury / prevention & control
Nitric Oxide / metabolism
Nitric Oxide Synthase / antagonists & inhibitors
Rats
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 10102-43-9/Nitric Oxide; 58-61-7/Adenosine; EC 1.14.13.39/Nitric Oxide Synthase
Comments/Corrections
Comment On:
Br J Pharmacol. 2005 Jul;145(6):703-11   [PMID:  15895104 ]

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