| Cardioprotection techniques: preconditioning, postconditioning and remote conditioning (basic science). | |
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MedLine Citation:
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PMID: 23270554 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. The major pathological consequences of IHD arise from the detrimental effects of acute ischemia-reperfusion injury (IRI) on the myocardium. Therefore, in order to improve clinical outcomes in patients with IHD, novel therapeutic strategies are required to protect the myocardium from acute IRI and preserve cardiac function (cardioprotection). In this regard, endogenous cardioprotective strategies such as ischemic preconditioning (IPC), ischemic postconditioning (IPost) and remote ischemic conditioning (RIC) may provide novel approaches for protecting the heart in clinical settings in which the patient experiences acute myocardial IRI. In this review article, we provide an overview of these endogenous cardioprotective strategies with respect to the pre-clinical experimental literature, exploring their major characteristics and underlying signaling mechanisms. The application of these therapeutic strategies in the clinical setting for potential patient benefit is reviewed in another article in this special issue. |
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Authors:
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Derek J Hausenloy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-21 |
Journal Detail:
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Title: Current pharmaceutical design Volume: - ISSN: 1873-4286 ISO Abbreviation: Curr. Pharm. Des. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The Hatter Cardiovascular Institute, University College London Hospital & Medical School, 67 Chenies Mews, London, WC1E 6HX, UK. d.hausenloy@ucl.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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