| Cardioprotection by kappa-opioid receptor agonist U50488H is mediated by opioidergic regulation but not by calcium current modulation. | |
| | |
MedLine Citation:
|
PMID: 20498795 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Because the kappa-opioid receptor (OR) agonist U50488H stimulates opioidergic regulation and inhibits L-type Ca(2+) channels, this study was aimed at assessing the roles of OR and L-type Ca(2+) channels on U50488H-induced cardioprotection. METHODS: Langendorff-perfused rat hearts were subjected to 30 min of regional ischemia and 2 h of reperfusion. Isolated hearts were treated with U50488H with or without the kappa-OR antagonist nor-binaltorphimine (nor-BNI) or the Ca(2+) channels activator BAY K 8644. Infarct size was measured with 2,3,5-triphenyltetrazolium chloride staining. RESULTS: U50488H treatment at reperfusion: (1) significantly reduced infarct size (11.3 +/- 1.3%) compared to control hearts (27.7 +/- 1.1%, P < 0.001), an effect that was completely blocked by nor-BNI (24.0 +/- 0.9%, P < 0.001 vs. U50488H) but not by BAY K 8644 (7.1 +/- 1.7%, P > 0.05 vs. U50488H); (2) significantly increased left ventricular developed pressure (65.3 +/- 4.8%) after 2 h of reperfusion compared to control hearts (44.8 +/- 3.6%, P < 0.05), an effect that was abrogated by nor-BNI (40.5 +/- 4.5%, P > 0.05 vs. control) but not by BAY K 8644 (64.3 +/- 5.6%, P < 0.01 vs. control); and (3) significantly decreased heart rate (P < 0.01 vs. control), an effect that was completely abrogated by both nor-BNI and BAY K 8644. CONCLUSIONS: U50488H significantly limits myocardial infarction and stunning in isolated rat hearts after ischemia-reperfusion induction. The infarct size limitation and contractility improvement observed with U50488H treatment during reperfusion are entirely mediated by OR stimulation and not by Ca(2+) channel modulation. |
| | |
Authors:
|
Kook Jin Chun; Young Ho Jang; June Hong Kim; Jun Kim; Yong Hyun Park |
Related Documents
:
|
16961265 - Effect of electroacupuncture on reperfusion ventricular arrhythmia in rat. 12568915 - Ssr69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-rep... 6617695 - Cardioprotection with calcium antagonists by suppression of early ischaemia and reperfu... 19800815 - Amiodarone for the prevention of reperfusion ventricular fibrillation. 15496265 - Peripartum cardiomyopathy: current therapeutic perspectives. 2760995 - Risk factors in a community experience with carotid endarterectomy. |
Publication Detail:
|
Type: Journal Article Date: 2010-02-28 |
Journal Detail:
|
Title: Korean journal of anesthesiology Volume: 58 ISSN: 2005-7563 ISO Abbreviation: Korean J Anesthesiol Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-05-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101502451 Medline TA: Korean J Anesthesiol Country: Korea (South) |
Other Details:
|
Languages: eng Pagination: 162-8 Citation Subset: - |
Affiliation:
|
Institute of Cardiovascular Research Center, Pusan National University Yangsan Hospital, Yangsan, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of propofol on cardiac function and gene expression after ischemic-reperfusion in isolated ra...
Next Document: Polyphenol (-)-epigallocatechin gallate targeting myocardial reperfusion limits infarct size and imp...