| Cardioprotection by beta-blockers: molecular and structural aspects in experimental hypertension. | |
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MedLine Citation:
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PMID: 1974839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper deals with some changes at the cardiac and aortic levels observed in normotensive rats and in hypertensive rats and turkeys by using two different beta-blockers, namely propranolol and oxprenolol. Chronic treatment with propranolol induced in the heart of normotensive rats a shift in the ventricular myosin pattern toward the "slow" V2 and V3 isoforms which are characterized by a reduced oxygen consumption. Oxprenolol treatment did not modify the blood pressure levels in the renal hypertensive rats nor in the spontaneously hypertensive turkeys. Nevertheless, in both experimental models a substantial modification of the media and intima, respectively, took place. In untreated hypertensive and normal rats the thickness of the aortic media was significantly higher than that of the treated ones, therefore suggesting a direct effect of oxprenolol on the smooth muscle cells of the aortic media. In the spontaneously hypertensive turkeys the atherosclerotic plaques appeared to be more frequent and thicker than those found in the oxprenolol-treated animals. These two experiments demonstrate that beta-blockers can prevent the development of hypertrophy of the media and decrease both the incidence and severity of intimal proliferations independently of blood pressure control. It therefore appears that the well-known myocardial protective effect played by beta-blockers, which mainly consists of a reduced myocardial oxygen consumption, is certainly obtained by reducing blood pressure and heart rate but also by changing the contractile protein pattern. In addition, an indirect myocardial protective effect could be exerted by beta-blockers at the vascular level by preventing medial hypertrophy and the development of atherosclerosis. |
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Authors:
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P Pauletto; G Vescovo; G Scannapieco; A C Pessina; C Dal Palù |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drugs under experimental and clinical research Volume: 16 ISSN: 0378-6501 ISO Abbreviation: Drugs Exp Clin Res Publication Date: 1990 |
Date Detail:
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Created Date: 1990-09-27 Completed Date: 1990-09-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802135 Medline TA: Drugs Exp Clin Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 123-8 Citation Subset: IM |
Affiliation:
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Institute of Clinical Medicine, University of Padua, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Animals Aorta / drug effects, physiopathology Blood Pressure / drug effects Calcium-Transporting ATPases / metabolism Cardiomegaly / prevention & control Coronary Artery Disease / drug therapy, physiopathology Heart / drug effects, physiopathology Heart Rate / drug effects Hypertension / drug therapy*, physiopathology Male Myocardium / enzymology Organ Size / drug effects Oxprenolol / therapeutic use Propranolol / therapeutic use Rats Rats, Inbred Strains Turkeys |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 525-66-6/Propranolol; 6452-71-7/Oxprenolol; EC 3.6.1.8/Calcium-Transporting ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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