| Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers. | |
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MedLine Citation:
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PMID: 15990736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the availability of interventional catheterization for patients with acute coronary syndromes, there is an unavoidable delay until the occluded coronary artery(s) can be revascularized, during which time persistent ischemia may lead to irreversible myocardial damage despite subsequently high patency rates. Accordingly, there has been an intense effort to develop early interventions that will preserve the viability of ischemic myocardium before revascularization. A number of novel strategies have been studied, including hemoglobin-based oxygen carriers. These compounds transport oxygen in the plasma to help maintain more normal oxygen delivery to the myocardium supplied by a thrombosed vessel, and they also release oxygen to tissue more efficiently than intraerythrocytic hemoglobin. |
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Authors:
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Daniel Burkhoff; David J Lefer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American heart journal Volume: 149 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-07-01 Completed Date: 2005-12-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 573-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Circulatory Physiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. db59@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Substitutes / administration & dosage, chemistry, pharmacokinetics, therapeutic use* Cardiotonic Agents / administration & dosage, chemistry, pharmacokinetics, therapeutic use* Clinical Trials, Phase II as Topic Drug Design Drug Evaluation, Preclinical Female Hemoglobins / administration & dosage, chemistry, pharmacokinetics, therapeutic use* Humans Male Middle Aged Multicenter Studies as Topic Myocardial Infarction / drug therapy, surgery, therapy Myocardial Ischemia / drug therapy, surgery, therapy* Myocardial Reperfusion Injury / prevention & control Myocardial Revascularization* Myocardium / metabolism Oxygen / metabolism Pilot Projects Preoperative Care* Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Cardiotonic Agents; 0/HBOC 201; 0/Hemoglobins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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