Document Detail

Cardioprotection: A Review of Current Practice in Global Ischemia and Future Translational Perspective.
MedLine Citation:
PMID:  25276778     Owner:  NLM     Status:  Publisher    
The idea of protecting the heart from ischemic insult during heart surgery to allow elective cardiac arrest is as old as the idea of cardiac surgery itself. The current gold standard in clinical routine is a high potassium regimen added either to crystalloid or blood cardioplegic solutions inducing depolarized arrest. Ongoing patient demographic changes with increasingly older, comorbidly ill patients and increasing case complexity with increasingly structurally abnormal hearts as morphological correlate paired with evolutions in pediatric cardiac surgery allowing more complex procedures than ever before redefine requirements for cardioprotection. Many, in part adversarial, regimens to protect the myocardium from ischemic insults have entered clinical routine; however, functional recovery of the heart is still often impaired due to perfusion injury. Myocardial reperfusion damage is a key determinant of postoperative organ functional recovery, morbidity, and mortality in adult and pediatric patients. There is a discrepancy between what current protective strategies are capable of and what they are expected to do in a rapidly changing cardiac surgery community. An increased understanding of the molecular players of ischemia reperfusion injury offers potential seeds for new cardioprotective regimens and may further displace boundaries of what is technically feasible.
Andreas Habertheuer; Alfred Kocher; Günther Laufer; Martin Andreas; Wilson Y Szeto; Peter Petzelbauer; Marek Ehrlich; Dominik Wiedemann
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Publication Detail:
Type:  REVIEW     Date:  2014-9-8
Journal Detail:
Title:  BioMed research international     Volume:  2014     ISSN:  2314-6141     ISO Abbreviation:  Biomed Res Int     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-2     Completed Date:  -     Revised Date:  2014-10-3    
Medline Journal Info:
Nlm Unique ID:  101600173     Medline TA:  Biomed Res Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  325725     Citation Subset:  -    
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