| Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats. | |
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MedLine Citation:
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PMID: 20123239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to investigate whether adding emulsified isoflurane to St Thomas cardioplegia solution could enhance the cardiac protection after cardioplegic arrest in rats. DESIGN: A randomized, blind study. SETTING: A university laboratory. PARTICIPANTS: Thirty male Sprague-Dawley rats. INTERVENTIONS: Thirty isolated heart preparations were randomly divided into 3 groups (n = 10/group) according to the different cardioplegia solutions being given: St Thomas solution mixed with emulsified isoflurane (containing 2.8% of isoflurane, group EI), St Thomas solution mixed with emulsified Intralipid (Huarui Pharmacy, Wuxi, Jiangsu, China) (group EL), and St Thomas solution alone (group St). In the 35-minute normothermic ischemia period, infusion of cardioplegia solution was repeated every 15 minutes. After the 35-minute ischemia period, the heart was perfused with Krebs-Henseleit buffer for another 2 hours. MEASUREMENTS AND MAIN RESULTS: The functional parameters of the heart were monitored throughout the experiments. The coronary effluent was collected for measuring the activity of CK-MB 30 minutes after reperfusion, and the infarct size was assessed at the end of reperfusion. The infarct size in group EI (24% +/- 4%) was reduced when compared with that in group EL (31% +/- 8%, p < 0.05) and group St (43% +/- 9%, p < 0.001). The CK-MB activity in group EI was decreased significantly when compared with that in group EL and group St (p < 0.05). The functional recovery in group EI also was improved. Compared with standard St Thomas solution alone, adding 30% Intralipid alone also significantly reduced the infarct size and the CK-MB leakage and improved the recovery of the mechanical function. CONCLUSIONS: St Thomas cardioplegia solution supplemented with emulsified isoflurane enhanced its cardioprotection in an isolated heart ischemia reperfusion injury model in rats. |
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Authors:
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Han Huang; Wensheng Zhang; Shanling Liu; Chen Yanfang; Tao Li; Jin Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 24 ISSN: 1532-8422 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 99-103 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, PR China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Inhalation
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pharmacology* Animals Bicarbonates / chemistry, pharmacology Calcium Chloride / chemistry, pharmacology Cardioplegic Solutions / pharmacology* Creatine Kinase, MB Form / analysis Disease Models, Animal Fat Emulsions, Intravenous / pharmacology Heart / drug effects* Hemodynamics / drug effects Isoflurane / pharmacology* Magnesium / chemistry, pharmacology Male Myocardial Infarction / pathology, prevention & control Potassium Chloride / chemistry, pharmacology Random Allocation Rats Rats, Sprague-Dawley Reperfusion Injury / drug therapy* Sodium Chloride / chemistry, pharmacology Therapeutics |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Bicarbonates; 0/Cardioplegic Solutions; 0/Fat Emulsions, Intravenous; 0/St. Thomas' Hospital cardioplegic solution; 10043-52-4/Calcium Chloride; 26675-46-7/Isoflurane; 7439-95-4/Magnesium; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride; EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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