| Cardioplegia preserves hypoxic response in isolated coronary arteries but not in isolated hearts. | |
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MedLine Citation:
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PMID: 9146319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Experiments were designed to determine whether hyperkalemic crystalloid cardioplegic solution alters the hypoxic response of isolated segments of rabbit coronary arteries. METHODS: Coronary arteries were suspended in organ chambers to measure isometric force. We measured the coronary perfusion pressure at a constant flow rate in isolated Langendorff-perfused hearts. Coronary arteries and hearts were preserved in warm (37 degrees C) physiologic solution or in cold (10 degrees C) crystalloid cardioplegic solution. RESULTS: In all groups of coronary arteries, the acetylcholine-induced relaxation before and after preservation was unchanged (n = 7). Hypoxia (15 mm Hg) caused an endothelium-dependent contraction, the amplitude of which did not change after cardioplegia. Conversely, in coronary arteries preserved in physiologic solution, hypoxic contraction amplitude decreased by 67% +/- 17%. In isolated hearts, hypoxic perfusion (15 mm Hg) induced a vasodilation. In all groups, the second hypoxic vasodilation was significantly greater (group 1, first hypoxic perfusion 2.8% +/- 2.8%, second hypoxic perfusion 18.2% +/- 7.1%; group 2, first hypoxic perfusion 6.8% +/- 1.5%, second hypoxic perfusion 29% +/- 9%). CONCLUSIONS: The crystalloid cardioplegic solution did not change the hypoxic response in isolated hearts and preserved the endothelium-dependent hypoxic contraction in coronary arteries. |
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Authors:
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C C Barbé; F F Diemont; P M Bonnet |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 63 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-05-28 Completed Date: 1997-05-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1303-8 Citation Subset: AIM; IM |
Affiliation:
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UMR Centre National de la Recherche Scientifique 6542, Faculté des Sciences, Tours, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / physiopathology* Cardioplegic Solutions* / pharmacology Coronary Vessels / drug effects, physiology* Endothelium, Vascular / drug effects, physiology Heart / drug effects, physiology* Heart Arrest, Induced Rabbits Vasodilation |
| Chemical | |
Reg. No./Substance:
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0/Cardioplegic Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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