Document Detail

Cardiomyopathy associated with amphetamine administration.
MedLine Citation:
PMID:  132114     Owner:  NLM     Status:  MEDLINE    
A 45-year-old woman with congestive heart failure, in whom there was no evidence of coronary heart disease, valve disease, or other demonstrable cause of heart failure, was found to have taken high doses of dextroamphetamine over a long period. Withdrawal of amphetamine resulted in deterioration, suggesting a physical cardiac dependence on the drug. The clinical and autopsy findings are presented and the similarities to the myocarditis associated with pheochromocytoma are discussed. The evidence presented suggests a causal relationship between administration of dextroamphetamine and the cardiomyopathy.
H J Smith; A H Roche; M F Jausch; P B Herdson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  91     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  792-7     Citation Subset:  AIM; IM    
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MeSH Terms
Amphetamines / adverse effects*,  therapeutic use
Cardiomegaly / chemically induced*
Depression / drug therapy
Heart Failure / chemically induced*
Middle Aged
Myocardium / pathology,  ultrastructure
Radiography, Thoracic
Substance-Related Disorders
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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