Document Detail


Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy.
MedLine Citation:
PMID:  21377520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aging is associated with an increased incidence of heart failure, but the existence of an age-related cardiomyopathy remains controversial. Differences in strain, age and technique of measuring cardiac function differ between experiments, confounding the interpretation of these studies. Additionally, the structural and genetic profile at the onset of heart failure has not been extensively studied. We therefore performed serial echocardiography, which allows repeated assessment of left ventricular (LV) function, on a cohort of the same mice every 3 months as they aged and demonstrated that LV systolic dysfunction becomes apparent at 18 months of age. These aging animals had left ventricular hypertrophy and fibrosis, but did not have inducible ventricular tachyarrhythmias. Gene expression profiling of left ventricular tissue demonstrated 40 differentially expressed probesets and 36 differentially expressed gene ontology terms, largely related to inflammation and immunity. At this early stage of cardiac dysfunction, we observed increased cardiomyocyte expression of the pro-apoptotic activated caspase-3, but no actual increase in apoptosis. The aging hearts also have higher levels of anti-apoptotic and autophagic factors, which may have rendered protection from apoptosis. In conclusion, we describe the functional, structural and genetic changes in murine hearts as they first develop cardiomyopathy of aging.
Authors:
Andrew J Boyle; Henry Shih; Joy Hwang; Jianqin Ye; Brian Lee; Yan Zhang; David Kwon; Kristine Jun; Daiwei Zheng; Rich Sievers; Franca Angeli; Yerem Yeghiazarians; Randall Lee
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-03
Journal Detail:
Title:  Experimental gerontology     Volume:  46     ISSN:  1873-6815     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-05-30     Completed Date:  2011-09-28     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  549-59     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aging / pathology,  physiology*
Animals
Apoptosis
Autophagy
Cardiomyopathies / diagnosis,  etiology*,  metabolism,  physiopathology
Echocardiography
Fibrosis
Gene Expression Profiling
Heart / physiology*
Hypertrophy
Hypertrophy, Left Ventricular / diagnosis,  etiology*,  metabolism,  physiopathology
Male
Mice
Mice, Inbred C57BL
Myocytes, Cardiac / pathology
Systole
Ventricular Dysfunction, Left / diagnosis,  etiology*,  metabolism,  physiopathology
Grant Support
ID/Acronym/Agency:
K08 HL090915/HL/NHLBI NIH HHS; K08 HL090915-03/HL/NHLBI NIH HHS
Comments/Corrections

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