| Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy. | |
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MedLine Citation:
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PMID: 21377520 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aging is associated with an increased incidence of heart failure, but the existence of an age-related cardiomyopathy remains controversial. Differences in strain, age and technique of measuring cardiac function differ between experiments, confounding the interpretation of these studies. Additionally, the structural and genetic profile at the onset of heart failure has not been extensively studied. We therefore performed serial echocardiography, which allows repeated assessment of left ventricular (LV) function, on a cohort of the same mice every 3 months as they aged and demonstrated that LV systolic dysfunction becomes apparent at 18 months of age. These aging animals had left ventricular hypertrophy and fibrosis, but did not have inducible ventricular tachyarrhythmias. Gene expression profiling of left ventricular tissue demonstrated 40 differentially expressed probesets and 36 differentially expressed gene ontology terms, largely related to inflammation and immunity. At this early stage of cardiac dysfunction, we observed increased cardiomyocyte expression of the pro-apoptotic activated caspase-3, but no actual increase in apoptosis. The aging hearts also have higher levels of anti-apoptotic and autophagic factors, which may have rendered protection from apoptosis. In conclusion, we describe the functional, structural and genetic changes in murine hearts as they first develop cardiomyopathy of aging. |
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Authors:
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Andrew J Boyle; Henry Shih; Joy Hwang; Jianqin Ye; Brian Lee; Yan Zhang; David Kwon; Kristine Jun; Daiwei Zheng; Rich Sievers; Franca Angeli; Yerem Yeghiazarians; Randall Lee |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-03 |
Journal Detail:
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Title: Experimental gerontology Volume: 46 ISSN: 1873-6815 ISO Abbreviation: Exp. Gerontol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-05-30 Completed Date: 2011-09-28 Revised Date: 2013-05-26 |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 549-59 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Division of Cardiology, University of California San Francisco, San Francisco, CA 94143, United States. aboyle@medicine.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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pathology,
physiology* Animals Apoptosis Autophagy Cardiomyopathies / diagnosis, etiology*, metabolism, physiopathology Echocardiography Fibrosis Gene Expression Profiling Heart / physiology* Hypertrophy Hypertrophy, Left Ventricular / diagnosis, etiology*, metabolism, physiopathology Male Mice Mice, Inbred C57BL Myocytes, Cardiac / pathology Systole Ventricular Dysfunction, Left / diagnosis, etiology*, metabolism, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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K08 HL090915-03/HL/NHLBI NIH HHS; K08 HL090915-04/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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