Document Detail

Cardiomyopathies and mitochondrial DNA mutations.
MedLine Citation:
PMID:  9406174     Owner:  NLM     Status:  MEDLINE    
Our former studies concerning mitochondrial DNA mutations were reviewed in this article. A 7.4 kb deletion between the D-loop and ATPase 6 genes was detected in myocardial tissue obtained at autopsy from patients with myocardial infarction, diabetes mellitus and also patients treated with adriamycin. A case with diabetes mellitus and hypertrophic cardiomyopathy is demonstrated which revealed a point mutation from adenine to guanine at position 3243 within tRNA Leu(UUR).
N Takeda
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  176     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-23     Completed Date:  1998-01-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  287-90     Citation Subset:  IM    
Department of Internal Medicine, Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan.
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MeSH Terms
Adenosine Triphosphatases / genetics
Cardiomyopathies / genetics*
DNA, Mitochondrial / genetics*
Diabetes Mellitus / genetics*
Doxorubicin / therapeutic use
Gene Deletion
Insulin / genetics
Middle Aged
Myocardial Infarction / genetics*
Neoplasms / drug therapy
Point Mutation / genetics
Polymerase Chain Reaction
RNA, Transfer, Leu / genetics*
Ventricular Function
Reg. No./Substance:
0/DNA, Mitochondrial; 0/RNA, Transfer, Leu; 11061-68-0/Insulin; 23214-92-8/Doxorubicin; EC 3.6.1.-/Adenosine Triphosphatases

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