Document Detail


Cardiometabolic consequences of gestational dysglycemia.
MedLine Citation:
PMID:  23524050     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The development of gestational diabetes and even milder forms of dysglycemia during pregnancy represents a maternal phenotype at increased subsequent risk of developing type 2 diabetes mellitus, metabolic syndrome, and with time, overt cardiovascular disease. A careful and systematic dissection of the hormonal, metabolic, and vascular changes occurring in such women during pregnancy and over post-partum years provides a unique opportunity to identify conventional and novel conditions and biomarkers whose modification may attenuate adverse long term outcomes, particularly cardiovascular risk. The purpose of this review is to summarize current understanding of the magnitude of such risk and its potential causes, with a particular focus on alterations post-partum in endothelial and vascular smooth muscle responsiveness.
Authors:
Shireen Brewster; Bernard Zinman; Ravi Retnakaran; John S Floras
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-20
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  -     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Affiliation:
Mount Sinai Hospital Department of Medicine, University of Toronto; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto.
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