| Cardiometabolic Risk in Chinese Women with Prior Gestational Diabetes: A 15-Year Follow-Up Study. | |
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MedLine Citation:
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PMID: 22179684 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: The progression to type 2 diabetes mellitus (DM) and other long-term cardiometabolic risks in Chinese women with prior history of gestational diabetes (GD) was studied at 15 years postpartum. Methods: 139 Chinese women (45 with GD and 94 with normal glucose tolerance (NGT) at the index pregnancy) who had their insulin sensitivity and β-cell functions examined at 8 years postpartum were again followed up at 15 years for the investigation of the rate of type 2 DM, hypertension and metabolic syndrome. Results: Women with prior history of GD had a significantly higher rate of hypertension (35.6% vs. 16.0%, p = 0.01), type 2 DM (24.4% vs. 5.3%, p < 0.001) and impaired glucose regulation (26.6% vs. 14.9%, p < 0.001) than women with NGT during the index pregnancy. The Matsuda insulin sensitivity index and the quantitative insulin sensitivity check index at 8 years postpartum were independent predictors of both DM and metabolic syndrome at 15 years postpartum. Conclusions: The conversion rate of type 2 DM increased at an average rate of 1.6% per year after a pregnancy affected by GD. Insulin resistance at 8 years postpartum could refine a future diabetic risk in women with prior history of GD. |
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Authors:
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Wing-Hung Tam; Ronald Ching-Wan Ma; Xilin Yang; Gary Tin-Choi Ko; Terence Tzu-Hsi Lao; Michael Ho-Ming Chan; Christopher Wai-Kei Lam; Clive Stewart Cockram; Juliana Chung-Ngor Chan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: - ISSN: 1423-002X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, SAR, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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