Document Detail


Cardiologic and neuromuscular co-morbidity influences mortality of patients with left ventricular hypertrabeculation/noncompaction: comparison with the Austrian general population.
MedLine Citation:
PMID:  17375885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Left ventricular hypertrabeculation/noncompaction (LVHT) is characterized by prominent trabeculations and intertrabecular recesses. LVHT patients suffer from heart failure, arrhythmias, chest pain and neuromuscular disorders (NMD). Data about long-term prognosis of LVHT are controversial. The aim of the study was to compare the mortality of LVHT patients with that of the Austrian general population and to assess which clinical and echocardiographic parameters influence mortality, and if mortality differs between patients with and without NMD. METHODS AND RESULTS: In 86 patients LVHT was diagnosed echocardiographically between June 1995 and December 2004 (21 women, mean age 52 +/- 14, range 14 - 94 years). A specific NMD was diagnosed in 21, a NMD of unknown aetiology in 33, the neurologic investigation was normal in 13 and 19 patients refused examination. During a mean follow-up of 51 months (range 3 - 106 months) the mortality rate was 5.3%/year. Compared with the lifetable from the Austrian general population and considering the sex, the standardized mortality ratio (SMR) of LVHT patients was 5.584 (95% CI 3.562-8.754, p = 0.000). The SMR was high in LVHT patients with NMD of unknown aetiology, who refused the neurologic investigation, with heart failure, diabetes mellitus, syncope, ventricular ectopic beats, pathologic Q waves, left anterior hemiblock, atrial fibrillation and low-voltage ECG. Patients with more extensive LVHT had a high SMR. CONCLUSIONS: Mortality in LVHT patients is higher than in the general population and cardiac and neurologic morbidity is the presumed cause for the increased mortality.
Authors:
Claudia Stöllberger; Maria Winkler-Dworak; Gerhard Blazek; Josef Finsterer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  62     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-04-24     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Second Medical Department, Krankenanstalt Rudolfstiftung, Wien, Austria. claudia.stoellberger@chello.at
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Austria / epidemiology
Cardiovascular Diseases / complications*
Comorbidity
Female
Humans
Hypertrophy, Left Ventricular / mortality*
Male
Middle Aged
Neuromuscular Diseases / complications*
Prognosis
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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