Document Detail

Cardiolipin and β₂-Glycoprotein I antibodies associate with cognitive impairment and seizure frequency in developmental disorders.
MedLine Citation:
PMID:  21377902     Owner:  NLM     Status:  MEDLINE    
Cardiolipin (CL) and β(2)-Glycoprotein I (β(2)-GpI) antibodies have been shown to associate with various neurological symptoms including seizures and cognitive dysfunction. Here we studied the prevalence of CL, β(2)-GpI and antinuclear (ANA) antibodies in 74 patients with various developmental disorders with epilepsy and 70 healthy controls. Developmental disorders were classified into genetic syndromes and diseases, genetic and/or acquired conditions, cortical dysgenesias and acquired encephalopathias. IgM-CL and β(2)-GpI antibodies were significantly more common in patients (46% vs. 20%, p<0.001 and 10% vs. 0%, p<0.05). Patients with most frequent seizures were more likely to have IgM-CL antibodies. The risk for positive IgM-CL, IgG-CL and β(2)-GpI antibodies increased concomitantly with increasing intellectual disability. Present data demonstrates that epilepsy with frequently recurring seizures may be associated with secondary immune system activation.
K A Lehtimäki; J Peltola; S Liimatainen; A-M Haapala; M Arvio
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-05
Journal Detail:
Title:  Seizure     Volume:  20     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-13     Completed Date:  2011-10-06     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  438-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Antibodies, Antinuclear / immunology
Anticonvulsants / therapeutic use
Autoantibodies / immunology*
Cardiolipins / immunology*
Cognition Disorders / immunology*
Developmental Disabilities / immunology*
Drug Therapy, Combination
Epilepsy / immunology
Immunoglobulin G / immunology
Immunoglobulin M / analysis
Intelligence Tests
Middle Aged
Seizures / epidemiology,  immunology*
Young Adult
beta 2-Glycoprotein I / immunology*
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Anticonvulsants; 0/Autoantibodies; 0/Cardiolipins; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/beta 2-Glycoprotein I

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