Document Detail

Cardioinhibitory properties of potato glycoalkaloids in beetles.
MedLine Citation:
PMID:  20024528     Owner:  NLM     Status:  MEDLINE    
The semi-isolated heart bioassay was used to evaluate the effect of glycoalkaloids extracted from potato leaves on the heart contractile activity of three beetle species Zophobas atratus, Tenebrio molitor and Leptinotarsa decemlineata. The dose-response curves indicated species specific action of tested substances. Application of glycoalkaloids on the continuously perfused Z. atratus heart inhibited progressively frequency contractions; higher concentrations exerted short and reversible cardiac arrests. In the rest two beetle species tested glycoalkaloids caused no cardiotropic effect. In vivo bioassay with 1 day old Z. atratus pupae showed that the extract induces a negative inotropic effect on the heart.
Pawe? Marciniak; Zbigniew Adamski; Pawe? Bednarz; Malgorzata Slocinska; Kazimierz Ziemnicki; Filomena Lelario; Laura Scrano; Sabino A Bufo
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2009-12-19
Journal Detail:
Title:  Bulletin of environmental contamination and toxicology     Volume:  84     ISSN:  1432-0800     ISO Abbreviation:  Bull Environ Contam Toxicol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0046021     Medline TA:  Bull Environ Contam Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
Department of Animal Physiology and Development, Adam Mickiewicz University, Umultowska 89 Street, 61-614 Poznan, Poland.
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MeSH Terms
Alkaloids / toxicity*
Beetles / physiology*
Dose-Response Relationship, Drug
Heart / drug effects*
Insecticides / toxicity*
Myocardial Contraction / drug effects
Plant Extracts / pharmacology
Solanum tuberosum / chemistry*
Reg. No./Substance:
0/Alkaloids; 0/Insecticides; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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