Document Detail


Cardiogenic oscillations in spontaneous breathing airway signal reflect respiratory system mechanics.
MedLine Citation:
PMID:  21770903     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Heartbeat-related pressure oscillations appear at the airway opening. We investigated whether these cardiogenic oscillations (COS) - extracted from spontaneous breathing signals - reflect the compliance of the respiratory system. Methods: Fifteen volunteers breathed spontaneously at normal or reduced chest wall compliance, i.e. with and without thorax strapping, and at normal or reduced lung compliance, induced by positive end-expiratory pressure (PEEP). COS-related signals were extracted by averaging the flow and pressure curve sections, temporally aligned to the electrocardiogram signal. Results: COS-related airway pressure and flow curves correlated closely for each subject (r(2) =0.97±0.02, P<0.0001). At the unstrapped thorax, the oscillation's amplitudes were 0.07±0.03 cmH(2) O (pressure) and 22±10 ml/s (flow). COS-related pressure amplitudes correlated closely with the ratio of tidal volume divided by pressure amplitude (r(2) =0.88, P<0.001) and furthermore increased with either thorax strapping (P<0.001) or with increasing PEEP (P=0.049). Conclusion: We conclude that COS extracted from the pressure and flow signal reflect the compliance of the respiratory system and could potentially allow estimating respiratory system mechanics during spontaneous breathing.
Authors:
S Schumann; F Messmer; M Lichtwarck-Aschoff; C Haberthuer; J Guttmann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-20
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  -     ISSN:  1399-6576     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Acta Anaesthesiologica Scandinavica © 2011 The Acta Anaesthesiologica Scandinavica Foundation.
Affiliation:
Division for Experimental Anaesthesiology, University Medical Centre, Freiburg, Germany Department of Surgical Sciences, University Hospital Uppsala, Uppsala, Sweden Department of Anaesthesiology, Kantonsspital, Luzern, Switzerland.
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