Document Detail


Cardiogenesis: an embryological perspective.
MedLine Citation:
PMID:  20560033     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiogenesis, considered as the formation of new heart tissue from embryonic, postnatal, or adult cardiac progenitors, is a pivotal concept to understand the rationale of advanced therapies to repair the damaged heart. In this review, we focus on the cellular and molecular regulation of cardiogenesis in the developing embryo, and we dissect the complex interactions that control the diversification and maturation of a variety of cardiac cell lineages. Our aim is to show how the sophisticated anatomical structure of the adult four-chambered heart strongly depends on the fine regulation of the differentiation of cardiac progenitor cells. These events are shown to be progressive and dynamic as well as plastic, so that the patterned differentiation of distinct heart domains is highly dependent on signals provided by nonmyocardial heart components and extracardiac tissues. Finally, we present the core of our knowledge on cardiac embryogenesis in a biomedical context to provide a critical analysis on the logic of cell therapies designed to treat the failing heart.
Authors:
Ramón Muñoz-Chápuli; José M Pérez-Pomares
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-11-04
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  3     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-48     Citation Subset:  IM    
Affiliation:
Department of Animal Biology, Faculty of Science, University of Málaga, 29071 Málaga, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Body Patterning
Cell Differentiation* / genetics
Cell Lineage* / genetics
Gene Expression Regulation, Developmental
Gene Regulatory Networks
Heart / embryology*
Heart Failure / pathology,  physiopathology,  surgery
Humans
Myocardium / pathology
Organogenesis
Regeneration
Stem Cell Transplantation
Stem Cells / physiology*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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