Document Detail

Cardiocerebral protection by emulsified isoflurane during cardiopulmonary resuscitation.
MedLine Citation:
PMID:  25466299     Owner:  NLM     Status:  Publisher    
Although improvement in cardiopulmonary resuscitation (CPR) performance and the increasing success at achieving return of spontaneous circulation (ROSC) have been possible in recent years, the survival and discharge rates of post-cardiac arrest (CA) patients remain disappointing. The high mortality rate is attributed to whole-body ischemia/reperfusion (I/R) induced multi-organ dysfunction that is well known as post-cardiac arrest syndrome. Post-cardiac arrest myocardial dysfunction and brain injury are the main clinical features of this complex pathophysiological process. Previous evidences have shown that volatile anesthetics, such as isoflurane, trigger a powerful and highly integrated cell survival response during I/R period in multiple organs, including heart and brain, which reduces I/R injury. This effect that called anesthetic-induced postconditioning can be shown when volatile anesthetics are administered after the onset of ischemia and at the time of reperfusion. Emulsified isoflurane (EIso) is a new anesthetic for intravenous administration, which is conveniently feasible outside operating room. Therefore, we hypothesize that EIso postconditioning could provide the cardiocerebral protection, and combined with therapeutic hypothermia as sedative agent could produce enhanced cardiocerebral protection, which can result in significant improvement of neurologically intact post-cardiac arrest survival. We consider that it would become a feasible, safe and efficient cardiocerebral protective intervention in the prevention and alleviation of post-cardiac arrest syndrome, which would also improve the outcomes after CA.
Ya-Jie Zhang; Meng-Jun Wu; Yi Li; Hai Yu
Related Documents :
10608969 - Valvular heart disease. identifying and managing mitral and aortic lesions.
9264489 - Clinical significance of mitral regurgitation after acute myocardial infarction. surviv...
14565709 - Clinical spectrum of chronic rheumatic heart disease in india.
11568029 - Pathogenesis of mitral regurgitation in tachycardia-induced cardiomyopathy.
7137029 - Detection of mild aortic regurgitation by range-gated pulsed doppler echocardiograhy.
11926969 - Diastolic blood pressure-estimated left ventricular dp/dt.
6608399 - Surgery for postinfarction left ventricular aneurysm: prognosis and long-term follow-up.
9438169 - A late retroperitoneal hematoma mimicking acute appendicitis--an unusual complication o...
23641749 - Acquired left coronary artery fistula draining to the right ventricle after myocardial ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-17
Journal Detail:
Title:  Medical hypotheses     Volume:  -     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-3     Completed Date:  -     Revised Date:  2014-12-4    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of ADHD symptoms as a contributing factor to obesity in patients with MC4R mutations.
Next Document:  Associations between aspects of pain and cognitive performance and the contribution of depressive sy...