Document Detail

Cardioactive C(19)-Diterpenoid Alkaloids from the Lateral Roots of Aconitum carmichaeli "Fu Zi".
MedLine Citation:
PMID:  22223386     Owner:  NLM     Status:  In-Data-Review    
Bioassay-guided fractionation of an n-BuOH extract of the lateral roots of Aconitum carmichaeli. led to the isolation of 5 cardioactive C(19)-diterpenoid alkaloids: N-deethylaconine (1), beiwutinine (2), hypaconine (3), mesaconine (4), and 15α-hydroxyneoline (5). N-Deethylaconine and beiwutinine are new aconitine-type C(19)-diterpenoid alkaloids. Hypaconine was isolated from this species for the first time. Among them, mesaconine, hypaconine, and beiwutinine showed the strongest cardiac actions on the isolated perfused bullfrog heart. Furthermore, mesaconine has protective effects, including improved inotropic effect and left ventricular diastolic function, on myocardial ischemia-reperfusion injury in rat at a dose of 10(-9) mol/L. However, mesaconine has almost no effect on heart rate.
Xiu-Xiu Liu; Xi-Xian Jian; Xiu-Feng Cai; Ruo-Bing Chao; Qiao-Hong Chen; Dong-Lin Chen; Xiao-Liang Wang; Feng-Peng Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  60     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Department of Medicinal Analysis, West China College of Pharmacy, Sichuan University.
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