| Cardioactive C(19)-Diterpenoid Alkaloids from the Lateral Roots of Aconitum carmichaeli "Fu Zi". | |
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MedLine Citation:
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PMID: 22223386 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Bioassay-guided fractionation of an n-BuOH extract of the lateral roots of Aconitum carmichaeli. led to the isolation of 5 cardioactive C(19)-diterpenoid alkaloids: N-deethylaconine (1), beiwutinine (2), hypaconine (3), mesaconine (4), and 15α-hydroxyneoline (5). N-Deethylaconine and beiwutinine are new aconitine-type C(19)-diterpenoid alkaloids. Hypaconine was isolated from this species for the first time. Among them, mesaconine, hypaconine, and beiwutinine showed the strongest cardiac actions on the isolated perfused bullfrog heart. Furthermore, mesaconine has protective effects, including improved inotropic effect and left ventricular diastolic function, on myocardial ischemia-reperfusion injury in rat at a dose of 10(-9) mol/L. However, mesaconine has almost no effect on heart rate. |
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Authors:
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Xiu-Xiu Liu; Xi-Xian Jian; Xiu-Feng Cai; Ruo-Bing Chao; Qiao-Hong Chen; Dong-Lin Chen; Xiao-Liang Wang; Feng-Peng Wang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 60 ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 144-9 Citation Subset: IM |
Affiliation:
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Department of Medicinal Analysis, West China College of Pharmacy, Sichuan University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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