Document Detail

Cardioacceleratory effect of muscarinic blocking agents in the dog.
MedLine Citation:
PMID:  7202523     Owner:  NLM     Status:  MEDLINE    
To test whether the tachycardia in response to atropine after adrenergic blockade is partly due to a central excitatory action, the effects of atropine, methylatropine and methylscopolamine were compared in dogs in neurolept-anesthesia. The latter two agents proved to have effect, similar to atropine. A central action is therefore improbable. It was possible to partly abolish the tachycardia by hexamethonium. The cardioacceleration by atropine, methylatropine and methylscopolamine, so far as it is not caused by muscarinic receptor blockade, can be explained by the unmasking of an underlying acceleratory tone.
H A Schuil; J R Brunsting; H van der Molen; W G Zijlstra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  69     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
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MeSH Terms
Atropine / pharmacology
Heart Rate / drug effects*
Parasympatholytics / pharmacology*
Time Factors
Reg. No./Substance:
0/Parasympatholytics; 51-55-8/Atropine

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