Document Detail

Cardio-respiratory response to moderate chloral hydrate sedation in young lambs.
MedLine Citation:
PMID:  23289633     Owner:  NLM     Status:  Publisher    
AIM: Chloral hydrate (CH) is the most commonly used sedative for medical procedures and lung function tests in infancy. The aim was to determine whether moderate CH sedation affects airway function, lung volume, and ventilation. METHODS: Thirteen chronically instrumented 7-8 weeks old lambs were studied both before after CH sedation (50 mg/kg as intravenous bolus followed by 25 mg/kg/hour as continuous infusion). A nitrogen washout technique and lung mechanics analysis was used to assess functional residual capacity (FRC) and airway function. Moment analysis and lung clearance index were calculated as measures of gas mixing efficiency in distal airways. Respiratory rate, tidal volume, minute ventilation and indices of inspiratory drive were determined together with heart rate, blood pressure, and oxygenation. RESULTS: No significant CH-induced changes were found for gas mixing efficiency, FRC, or lung mechanics. Minute ventilation decreased slightly, but significantly, while indices of inspiratory drive remained unchanged. Heart rate increased significantly, but mean arterial blood pressure was unaffected. CONCLUSION: Moderate CH sedation did not significantly affect airway function or FRC. Although indices of inspiratory drive were not affected, minute ventilation decreased slightly. These findings indicate that reliable results can be obtained from lung function testing when CH is used for sedation. ©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Kenneth L Sandberg; Stanley D Poole; Hakan W Sundell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Department of Paediatrics, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
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