Document Detail

Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women.
MedLine Citation:
PMID:  19133315     Owner:  NLM     Status:  MEDLINE    
Short episodes of high intensity exercise transiently increase serum levels of BDNF in humans, but serum levels of BDNF at rest appear to be lower in more physically active humans with greater levels of energy expenditure. The relationship between serum BDNF concentration, cardio-respiratory fitness (Astrand-Rhyming test estimated VO2 max) and volume of long-term, regular exercise and sporting activity (Baecke Habitual Physical Activity Index) was investigated in 44 men and women between the age range of 18-57 years. In this group an inverse relationship between resting serum BDNF concentration and measures of both estimated VO2 max (r=-0.352; P<0.05) and long-term sporting activity (r=-0.428, P<0.01) was found. These results indicate that increased levels of cardio-respiratory fitness and habitual exercise are associated with lower resting levels of serum BDNF in healthy humans. This is the first study to demonstrate an inverse relationship between a physiological estimate of cardio-respiratory fitness and serum BDNF.
James Currie; Roger Ramsbottom; Helen Ludlow; Alan Nevill; Michael Gilder
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Publication Detail:
Type:  Journal Article     Date:  2008-12-25
Journal Detail:
Title:  Neuroscience letters     Volume:  451     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  152-5     Citation Subset:  IM    
School of Life Sciences, Oxford Brookes University, United Kingdom.
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MeSH Terms
Brain / metabolism*
Brain-Derived Neurotrophic Factor / blood*
Cardiovascular Physiological Phenomena*
Cross-Sectional Studies
Cytoprotection / physiology
Down-Regulation / physiology
Exercise Therapy*
Middle Aged
Oxygen Consumption / physiology
Physical Fitness / physiology*
Respiratory Physiological Phenomena*
Sex Characteristics
Young Adult
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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