Document Detail

Cardio-respiratory coupling indicates suppression of vagal activity in acute schizophrenia.
MedLine Citation:
PMID:  19406623     Owner:  NLM     Status:  MEDLINE    
Altered amygdala activity in patients with schizophrenia can influence respiratory patterns and consequently cardiovascular parameters. Hence, we examined respiration and heart rate time series complexity as well as coupling of both signals. Electrocardiograms and respiratory signals were obtained from 25 unmedicated patients with schizophrenia and controls. Approximate entropy (ApEn) was calculated for heart and respiratory rates as well as cross-ApEn reflecting coupling of both signals. Coupling was decreased indicating diminished vagal modulation at the brain stem level. Regularity of breathing correlated with disease severity. These data might reflect a lack of inhibitory control over brainstem centers in schizophrenia.
Jeannine Peupelmann; Michael Karl Boettger; Carmen Ruhland; Sandy Berger; Chaitra T Ramachandraiah; Vikram K Yeragani; Karl-Jürgen Bär
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-29
Journal Detail:
Title:  Schizophrenia research     Volume:  112     ISSN:  1573-2509     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-09-03     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  153-7     Citation Subset:  IM    
Department of Psychiatry and Psychotherapy, University Hospital, Philosophenweg 3, Jena, Germany.
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MeSH Terms
Electrocardiography / methods
Heart Rate / physiology*
Middle Aged
Multivariate Analysis
Nonlinear Dynamics
Respiratory Mechanics / physiology*
Schizophrenia / physiopathology*
Statistics, Nonparametric
Time Factors
Young Adult

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