Document Detail

Cardio-cerebrovascular protective effects of valsartan in high-risk hypertensive patients with overweight/obesity: A post-hoc analysis of the KYOTO HEART Study.
MedLine Citation:
PMID:  22795716     Owner:  NLM     Status:  Publisher    
PURPOSE: The objective was to examine whether baseline overweight/obesity influences the ARB, valsartan add-on effects on the cardio-cerebrovascular (CV) morbidity and mortality in the high-risk hypertensive patients who participated in the KYOTO HEART Study. METHODS AND RESULTS: The primary endpoint was the same as in the main study: a composite of defined CV events. Median follow-up period was 3.27years. According to the presence of overweight/obesity (body mass index≥25) at baseline, the study population was divided into two groups (with overweight/obesity; n=1177 and without overweight/obesity; n=1854), in which prevalence of primary endpoint events were similar in patients with overweight/obesity and patients without overweight/obesity (7.6% vs. 8.0%; HR 0.96, 95% CI 0.74-1.23). Valsartan add-on significantly decreased the occurrence of primary endpoint events in both overweight/obesity-positive patients (4.0% vs. 11.3%; HR 0.36, 95% CI 0.23-0.56) and overweight/obesity-negative patients (6.4% vs. 9.6%; HR 0.67, 95% CI 0.49-0.92) compared with non-ARB treatment. In the presence of overweight/obesity, the patients with valsartan add-on treatment had significantly smaller prevalence of new occurrence or exacerbation of angina pectoris, stroke, and heart failure than those with non-ARB treatment, while valsartan add-on effects on angina, stroke, and heart failure were not significant in the absence of overweight/obesity. Changes in blood pressure during the follow-up period did not differ significantly among the study subgroups. CONCLUSIONS: High-risk hypertensive patients with overweight/obesity might obtain more CV benefits from valsartan add-on treatment, compared with patients without overweight/obesity.
Hidekazu Irie; Jun Shiraishi; Takahisa Sawada; Masahiro Koide; Hiroyuki Yamada; Hiroaki Matsubara;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-12
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiology, Kyoto First Red Cross Hospital, Honmachi, Higashiyama-ku, Kyoto 605-0981, Japan.
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