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Cardio-Oncology Issues among Pediatric Cancer and Stem Cell Transplant Survivors.
MedLine Citation:
PMID:  24926805     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Improvements in the survival of children and adolescents diagnosed with cancer have resulted in a growing population of childhood, adolescent and adult cancer and stem cell transplant survivors. Approximately two-thirds of these survivors will experience at least one late effect of their treatment, and about one-third will experience a late effect that is severe or life threatening. Childhood cancer survivors are at high risk for development of severe cardiac disease, particularly after anthracycline and/or radiation exposure. Cardiotoxicity can present as early cardiac dysfunction during or shortly after therapy or as chronic impairment of cardiac function several years after treatment. Attempts to minimize serious adverse effects have included reduction of high dose chemotherapy, particularly anthracycline dosing to less than 350mg/m, use of cardioprotective agents such as dexrazoxane and decreased radiation dosing and radiation fields. There have been no convincing data showing medical interventions that can reliably slow or reverse cardiotoxicity in treated patients, which therefore warrants further studies looking at the use of beta blockers, angiotensin converting enzyme inhibitors, angiotensin receptor blockers or newer agents either prior to or following the discovery of heart damage. Emphasis on the prevention of further damage is critical and can be accomplished through aggressive surveillance, including screening for lipid abnormalities, cardiac biomarkers such as troponins and B-type natriuretic peptides, hypertension, diabetes and obesity as well as the use of echocardiography and cardiac magnetic resonance imaging to identify abnormalities early in their course. Here we provide an overview of the field of Cardio-Oncology to stimulate interest among cardiologists.
Authors:
Jessica C Hochberg; Mitchell S Cairo; Deborah M Friedman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-12
Journal Detail:
Title:  Cardiology in review     Volume:  -     ISSN:  1538-4683     ISO Abbreviation:  Cardiol Rev     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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