Document Detail

Cardio Ankle Vascular Index evaluations revealed that co-treatment of ARB Anti-hypertension medication with Traditional Chinese Medicine improved arterial functionality.
MedLine Citation:
PMID:  23188130     Owner:  NLM     Status:  Publisher    
ABSTRACT: Qian Yang He Ji (QYHJ) is a traditional Chinese medicine composed of Digitalis purpurea, Uncaria gambir, Fructus tribuli terrestris, Ligustrum lucidum. Here we explored whether combining an antihypertensive angiotensin II receptor blocker (ARB) therapy with QYHJ can improve the arterial functionality of hypertensive patients. 108 hypertension cases were randomized into two groups, one group (n=53) was treated with ARB and the other group (n=55) was treated with ARB combined with QYHJ. Each of the 2 groups included three sub-groups (pure hypertension, hypertension with diabetes and hypertension with coronary heart disease) and was further divided into patients with and without complications. The Cardio Ankle Vascular Index (CAVI) as well as Intima-Media Thickness (IMT) and pulse pressure (PP) were the outcome evaluation parameter. Combined QYHJ and ARB treatment reduced the values of CAVI, systolic blood pressure (SBP), diastolic blood pressure (DBP) and PP to significant lower levels than ARB treatment alone in hypertension patients after 6 months treatment. ARB improves hypertension, but a combined QYHJ treatment can additionally ameliorate the arterial functionality not only in solely hypertensive patients but also hypertensive patients with diabetes and coronary heart disease (CHD) complications. QYHJ co-application might be a choice to further improve the arterial functionality during an ARB hypertension treatment.
Yan Xu; Hua Yan; Jiemin Yao; Jie Ma; Meijun Jia; Xiaofen Ruan; Chengzeng Yao; Minhua Huang; Jing Zheng; Ting Chen; Hua Lv; Alexander Endler
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-22
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai, 201203, P.R.China 2Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai, 201203, P.R.China 3Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 164 Lanxi Road, Shanghai, 200062, P.R.China 4Department of Regenerative Medicine, School of Medicine, Tongji University, 1239 Siping Road, Shanghai,200092, P.R.China.
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