Document Detail


Cardinal roles of miRNA in cardiac development and disease.
MedLine Citation:
PMID:  22227903     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) are small noncoding RNAs that are emerging as pivotal modulators in virtually all aspects of cardiac biology, from cardiac development to cardiomyocyte survival and hypertrophy. The miRNA profiling, following gain- and loss-of-function studies using in vitro and in vivo models, has identified wide-ranging functions for miRNAs in the heart, providing new perspectives on their contributions to cardiac pathogenesis, and revealing potential therapeutic targets and diagnostic biomarkers. This review summarizes current progress in regulation of miRNAs in heart development and disease.
Authors:
Yuliang Feng; Xiyong Yu
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Publication Detail:
Type:  Journal Article     Date:  2012-01-07
Journal Detail:
Title:  Science China. Life sciences     Volume:  54     ISSN:  1869-1889     ISO Abbreviation:  Sci China Life Sci     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-01-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101529880     Medline TA:  Sci China Life Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  1113-20     Citation Subset:  IM    
Affiliation:
Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
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