Document Detail

Cardiac and vascular protection: the potential of ONTARGET.
MedLine Citation:
PMID:  18449380     Owner:  NLM     Status:  MEDLINE    
Cardiovascular risk is determined by multiple risk factors. Blockade of the renin-angiotensin system is an important approach to the prevention of cardiovascular events. In the largest angiotensin receptor blocker cardiovascular outcome study to date, the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) program will compare the efficacy of therapy with telmisartan and ramipril, in reducing cardiovascular events in patients at high risk (history of coronary artery disease, stroke or transient ischemic attack, peripheral artery disease, or diabetes with evidence of end-organ damage). Recruited patients (n = 31,546) will be followed up for a period of 6 years, and more than 150,000 patient-years of data will be recorded. The primary endpoint is a composite of cardiovascular death, stroke, acute myocardial infarction, and hospitalization for congestive heart failure; secondary endpoints focus on reductions in newly diagnosed heart failure, new-onset type 2 diabetes, cognitive decline, atrial fibrillation, and nephropathy. In addition, an ambulatory blood pressure monitoring substudy will be conducted to assess the effect of treatment on endpoints after adjustment for 24-hour blood pressure values. Other substudies of the treatment effects on erectile dysfunction, blood markers, arterial stiffness, oral glucose tolerance, and the progression of target organ damage are also planned. The results of the ONTARGET program are due in 2008, and the findings are expected to have important clinical implications for the management of patients at high cardiovascular risk.
Giuseppe Mancia; Anne Jakobsen; Jose Heroys; Ann Ralph; Tomas Rees; Michael Shaw
Publication Detail:
Type:  Journal Article; Review     Date:  2008-03-26
Journal Detail:
Title:  Medscape journal of medicine     Volume:  10 Suppl     ISSN:  1934-1997     ISO Abbreviation:  Medscape J Med     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-01     Completed Date:  2008-06-05     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101462763     Medline TA:  Medscape J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S7     Citation Subset:  IM    
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / administration & dosage*
Angiotensin-Converting Enzyme Inhibitors / administration & dosage*
Benzimidazoles / administration & dosage*
Benzoates / administration & dosage*
Cardiotonic Agents / administration & dosage*
Cardiovascular Diseases / prevention & control*
Clinical Trials as Topic*
Drug Delivery Systems / methods
Drug Therapy, Combination
Ramipril / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzimidazoles; 0/Benzoates; 0/Cardiotonic Agents; L35JN3I7SJ/Ramipril; U5SYW473RQ/telmisartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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