| Cardiac and vascular consequences of pre-hypertension in youth. | |
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MedLine Citation:
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PMID: 21545394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension is associated with increased left ventricular mass (LVM) and carotid intima-media thickness (cIMT), which predict cardiovascular (CV) events in adults. Whether target organ damage is found in pre-hypertensive youth is not known. The authors measured body mass index, blood pressure, fasting glucose, insulin, lipids and C-reactive protein, LVM/height(2.7) (LVM index), diastolic function, cIMT, carotid stiffness, augmentation index, brachial artery distensibility, and pulse wave velocity (PWV) in 723 patients aged 10 to 23 years (29% with type 2 diabetes mellitus). Patients were stratified by blood pressure level (normotensive: 531, pre-hypertensive: 65, hypertensive: 127). Adiposity and CV risk factors worsened across blood pressure group. There was a graded increase in cIMT, arterial stiffness, and LVM index and decrease in diastolic function from normotension to pre-hypertension to hypertension. In multivariable models adjusted for CV risk factors, status as pre-hypertension or hypertension remained an independent determinant of target organ damage for LVM, diastolic function, internal cIMT, and carotid and arterial stiffness. Pre-hypertension is associated with cardiovascular target organ damage in adolescents and young adults. |
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Authors:
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Elaine M Urbina; Philip R Khoury; Connie McCoy; Stephen R Daniels; Thomas R Kimball; Lawrence M Dolan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-21 |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 13 ISSN: 1751-7176 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-06 Completed Date: 2011-09-29 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 332-42 Citation Subset: IM |
Copyright Information:
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© 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. elaine.urbina@cchmc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Flow Velocity / physiology Blood Pressure / physiology Carotid Arteries / physiology*, ultrasonography* Child Cross-Sectional Studies Diabetes Mellitus, Type 2 / complications Echocardiography Elasticity / physiology* Female Humans Hypertrophy, Left Ventricular / ultrasonography* Male Obesity / complications Prehypertension / complications*, physiopathology Tunica Intima / ultrasonography* Tunica Media / ultrasonography* Ultrasonography Vascular Resistance / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL076269/HL/NHLBI NIH HHS; R01 HL076269-04/HL/NHLBI NIH HHS; R01 HL105591-02/HL/NHLBI NIH HHS; UL1 RR026314/RR/NCRR NIH HHS |
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