| Cardiac vascular calcification and QT interval in ESRD patients: is there a link? | |
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MedLine Citation:
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PMID: 16940716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We will present our experience and our preliminary data about the correlation between cardiac calcification and QT interval (and QT dispersion) in uraemia. We studied 32 haemodialysis (HD) patients (age 69 +/- 16 years, time on dialysis 32 +/- 27 months) and 12 chronic kidney disease stage 4 (CKD-4) patients (age 66 +/- 17 years, uraemia duration 38 +/- 16 months). The patients were characterized by a good mineral control, as shown by serum phosphate levels (3.6 +/- 1.3 mg/dl in CKD-4 and 4.3 +/- 1.6 mg/dl in HD patients) and Ca x P product (46 +/- 17 and 49 +/- 16 mg(2)/dl(2), respectively). The parathyroid hormone levels were higher in HD than CKD-4 patients (p < 0.0001). A TC score >400 was found to be highly prevalent in both groups. Significantly more HD patients (62.5%) showed cardiac calcification than CKD-4 patients (33%; p = 0.01). The patients were matched for TC scores higher or lower than 400. The two groups differed by gender (p < 0.05), age (p = 0.026), frequency of diabetes mellitus (p < 0.01), uraemia follow-up period (p < 0.001), low-density lipoprotein cholesterol level (p = 0.009), Ca x P product (p = 0.002), parathyroid hormone level (p < 0.0001), and corrected QT dispersion (p < 0.0001). The QT interval was higher in HD and CKD-4 patients with higher TC scores (approximately 11%), but QT interval dispersion was significantly higher in patients with TC scores >400. QT dispersion showed a linear correlation with TC scores in both groups (r = 0.899 and p < 0.0001 and r = 0.901 and p < 0.0001). Male gender, age, time (months) of uraemia, low-density lipoprotein cholesterol, albumin, calcium x phosphorus product, parathyroid hormone, and TC score are important determinants of QT dispersion. Our data show that it is possible to link dysrhythmias and cardiac calcification in uraemic patients. |
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Authors:
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Biagio R Di Iorio; Sara Bortone; Carmine Piscopo; Pellegrino Grimaldi; Emanuele Cucciniello; Ernesto D'Avanzo; Fiorentino Mondillo; Nicola Cillo; Vincenzo Bellizzi |
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Publication Detail:
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Type: Journal Article Date: 2006-08-25 |
Journal Detail:
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Title: Blood purification Volume: 24 ISSN: 0253-5068 ISO Abbreviation: Blood Purif. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-12-27 Completed Date: 2007-02-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: Switzerland |
Other Details:
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Languages: eng Pagination: 451-9 Citation Subset: IM |
Affiliation:
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UO di Nefrologia e Dialisi, PO 'A. Landolfi', Solofra, Italia. b.diiorio@tiscali.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aged, 80 and over Blood Proteins / analysis Calcinosis / blood, diagnosis, etiology, physiopathology* Calcium / blood Cardiovascular Diseases / blood, diagnosis, etiology, physiopathology* Electrocardiography* Female Follow-Up Studies Humans Kidney Failure, Chronic / blood, complications, physiopathology*, therapy Male Middle Aged Phosphates / blood Renal Dialysis Sex Factors Time Factors Uremia / blood, complications, physiopathology*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Phosphates; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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