Document Detail


Cardiac vascular calcification and QT interval in ESRD patients: is there a link?
MedLine Citation:
PMID:  16940716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We will present our experience and our preliminary data about the correlation between cardiac calcification and QT interval (and QT dispersion) in uraemia. We studied 32 haemodialysis (HD) patients (age 69 +/- 16 years, time on dialysis 32 +/- 27 months) and 12 chronic kidney disease stage 4 (CKD-4) patients (age 66 +/- 17 years, uraemia duration 38 +/- 16 months). The patients were characterized by a good mineral control, as shown by serum phosphate levels (3.6 +/- 1.3 mg/dl in CKD-4 and 4.3 +/- 1.6 mg/dl in HD patients) and Ca x P product (46 +/- 17 and 49 +/- 16 mg(2)/dl(2), respectively). The parathyroid hormone levels were higher in HD than CKD-4 patients (p < 0.0001). A TC score >400 was found to be highly prevalent in both groups. Significantly more HD patients (62.5%) showed cardiac calcification than CKD-4 patients (33%; p = 0.01). The patients were matched for TC scores higher or lower than 400. The two groups differed by gender (p < 0.05), age (p = 0.026), frequency of diabetes mellitus (p < 0.01), uraemia follow-up period (p < 0.001), low-density lipoprotein cholesterol level (p = 0.009), Ca x P product (p = 0.002), parathyroid hormone level (p < 0.0001), and corrected QT dispersion (p < 0.0001). The QT interval was higher in HD and CKD-4 patients with higher TC scores (approximately 11%), but QT interval dispersion was significantly higher in patients with TC scores >400. QT dispersion showed a linear correlation with TC scores in both groups (r = 0.899 and p < 0.0001 and r = 0.901 and p < 0.0001). Male gender, age, time (months) of uraemia, low-density lipoprotein cholesterol, albumin, calcium x phosphorus product, parathyroid hormone, and TC score are important determinants of QT dispersion. Our data show that it is possible to link dysrhythmias and cardiac calcification in uraemic patients.
Authors:
Biagio R Di Iorio; Sara Bortone; Carmine Piscopo; Pellegrino Grimaldi; Emanuele Cucciniello; Ernesto D'Avanzo; Fiorentino Mondillo; Nicola Cillo; Vincenzo Bellizzi
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Publication Detail:
Type:  Journal Article     Date:  2006-08-25
Journal Detail:
Title:  Blood purification     Volume:  24     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-27     Completed Date:  2007-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  451-9     Citation Subset:  IM    
Affiliation:
UO di Nefrologia e Dialisi, PO 'A. Landolfi', Solofra, Italia. b.diiorio@tiscali.it
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aged, 80 and over
Blood Proteins / analysis
Calcinosis / blood,  diagnosis,  etiology,  physiopathology*
Calcium / blood
Cardiovascular Diseases / blood,  diagnosis,  etiology,  physiopathology*
Electrocardiography*
Female
Follow-Up Studies
Humans
Kidney Failure, Chronic / blood,  complications,  physiopathology*,  therapy
Male
Middle Aged
Phosphates / blood
Renal Dialysis
Sex Factors
Time Factors
Uremia / blood,  complications,  physiopathology*,  therapy
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Phosphates; 7440-70-2/Calcium

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