Document Detail

Cardiac vascular calcification and QT interval in ESRD patients: is there a link?
MedLine Citation:
PMID:  16940716     Owner:  NLM     Status:  MEDLINE    
We will present our experience and our preliminary data about the correlation between cardiac calcification and QT interval (and QT dispersion) in uraemia. We studied 32 haemodialysis (HD) patients (age 69 +/- 16 years, time on dialysis 32 +/- 27 months) and 12 chronic kidney disease stage 4 (CKD-4) patients (age 66 +/- 17 years, uraemia duration 38 +/- 16 months). The patients were characterized by a good mineral control, as shown by serum phosphate levels (3.6 +/- 1.3 mg/dl in CKD-4 and 4.3 +/- 1.6 mg/dl in HD patients) and Ca x P product (46 +/- 17 and 49 +/- 16 mg(2)/dl(2), respectively). The parathyroid hormone levels were higher in HD than CKD-4 patients (p < 0.0001). A TC score >400 was found to be highly prevalent in both groups. Significantly more HD patients (62.5%) showed cardiac calcification than CKD-4 patients (33%; p = 0.01). The patients were matched for TC scores higher or lower than 400. The two groups differed by gender (p < 0.05), age (p = 0.026), frequency of diabetes mellitus (p < 0.01), uraemia follow-up period (p < 0.001), low-density lipoprotein cholesterol level (p = 0.009), Ca x P product (p = 0.002), parathyroid hormone level (p < 0.0001), and corrected QT dispersion (p < 0.0001). The QT interval was higher in HD and CKD-4 patients with higher TC scores (approximately 11%), but QT interval dispersion was significantly higher in patients with TC scores >400. QT dispersion showed a linear correlation with TC scores in both groups (r = 0.899 and p < 0.0001 and r = 0.901 and p < 0.0001). Male gender, age, time (months) of uraemia, low-density lipoprotein cholesterol, albumin, calcium x phosphorus product, parathyroid hormone, and TC score are important determinants of QT dispersion. Our data show that it is possible to link dysrhythmias and cardiac calcification in uraemic patients.
Biagio R Di Iorio; Sara Bortone; Carmine Piscopo; Pellegrino Grimaldi; Emanuele Cucciniello; Ernesto D'Avanzo; Fiorentino Mondillo; Nicola Cillo; Vincenzo Bellizzi
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Publication Detail:
Type:  Journal Article     Date:  2006-08-25
Journal Detail:
Title:  Blood purification     Volume:  24     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-27     Completed Date:  2007-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  451-9     Citation Subset:  IM    
UO di Nefrologia e Dialisi, PO 'A. Landolfi', Solofra, Italia.
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MeSH Terms
Age Factors
Aged, 80 and over
Blood Proteins / analysis
Calcinosis / blood,  diagnosis,  etiology,  physiopathology*
Calcium / blood
Cardiovascular Diseases / blood,  diagnosis,  etiology,  physiopathology*
Follow-Up Studies
Kidney Failure, Chronic / blood,  complications,  physiopathology*,  therapy
Middle Aged
Phosphates / blood
Renal Dialysis
Sex Factors
Time Factors
Uremia / blood,  complications,  physiopathology*,  therapy
Reg. No./Substance:
0/Blood Proteins; 0/Phosphates; 7440-70-2/Calcium

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