Document Detail

Cardiac valve calcifications and left ventricular hypertrophy in hemodialysis patients.
MedLine Citation:
PMID:  16350826     Owner:  NLM     Status:  MEDLINE    
Cardiac valve calcification (VC) is a common finding in end-stage renal disease patients. It was shown recently that VC is an independent predictor for all-cause and cardiovascular mortality in peritoneal dialysis patients. In hemodialysis (HD) patients, VC was associated with all-cause and cardiovascular mortality, but after adjusting for other cardiovascular risk factors and complications, as well as left ventricular mass index (LVMI), it lost significance. The aim of the study was to assess the relationship between VC and left ventricular hypertrophy in hemodialysis patients. Echocardiographic examination with mitral and aortic valves assessment and LVMI calculation was performed in 65 HD patients ages 49+/-12, with duration of HD therapy 38+/-32 months. VC were found in 32 of 65 patients (49%)-Group VC(+), mitral valve calcifications (MVC) in 10, aortic valve calcifications (AVC) in 9, and both valves calcifications (MVC+AVC) in 13 patients. Patients with VC were older, on HD therapy were longer, had higher systolic and pulse pressure, and had higher LVMI. Patients with both VCs had the highest LVMI. No significant differences were found with respect to Ca, P, PTH, and mean Ca x P product, but the incidence of Ca x P product above 4.43 mmol2/L2 was higher in VC(+) compared with those without VCs. VC coexists with left ventricular hypertrophy, particularly when both valves are calcified. Even short-lasting incidents of increased Ca x P product may lead to cardiac VC.
Pawe? Str?zecki; Grazyna Odrowaz-Sypniewska; Jacek Manitius
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  27     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-14     Completed Date:  2006-02-28     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  733-8     Citation Subset:  IM    
Department of Nephrology, Hypertension and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toru?, Poland.
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MeSH Terms
Age Distribution
Calcinosis / epidemiology,  etiology*,  ultrasonography
Case-Control Studies
Cohort Studies
Echocardiography, Doppler
Follow-Up Studies
Heart Valve Diseases / epidemiology,  etiology*,  ultrasonography
Hypertrophy, Left Ventricular / epidemiology,  etiology*,  ultrasonography
Kidney Failure, Chronic / diagnosis,  therapy
Middle Aged
Poland / epidemiology
Renal Dialysis / adverse effects*,  methods
Risk Assessment
Severity of Illness Index
Sex Distribution
Statistics, Nonparametric
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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