Document Detail


Cardiac vagal response to water ingestion in normal human subjects.
MedLine Citation:
PMID:  12149107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In healthy young subjects there is direct evidence for sympathetic vasoconstrictor activation after drinking water, but this is not accompanied by an increase in arterial blood pressure. A marked pressor response to water ingestion has, however, been observed in elderly subjects and in patients with autonomic failure. We examined the effect of water ingestion on haemodynamic variables and heart rate variability (HRV) markers of cardiac vagal control in ten healthy young subjects and four cardiac transplant recipients with confirmed persistent cardiac vagal denervation. In a random order crossover protocol, changes in heart rate, blood pressure and measures of high frequency (HF) HRV were compared over time following the ingestion of 500 ml and 20 ml (control) of tap water. In healthy subjects, after drinking 500 ml of water the heart rate fell from 67.6+/-2.0 (mean+/-S.E.M.) to 60.7+/-2.4 beats/min (P<0.01), and the bradycardic response peaked between 20 and 25 min. There were no significant changes in arterial blood pressure. Over the same time course, water ingestion caused increases in measurements of HF HRV: root-mean-square of successive RR interval differences (RMSSD) increased by 13+/-2.7 ms after 500 ml versus 2+/-3.1 ms after 20 ml (P<0.05); HF power increased by 686+/-400 versus -63+/-322 (P<0.01). In transplant recipients water ingestion was followed by a pressor response (range 13 to 29 mmHg). These results provide evidence that water ingestion in normal subjects is followed by an increase in cardiac vagal control that may counteract the pressor effects of sympathetic activation. We suggest that in the elderly, in transplant recipients and in autonomic failure, loss of this buffering mechanism explains the pressor response to drinking water.
Authors:
Helen C Routledge; Saqib Chowdhary; John H Coote; Jonathan N Townend
Related Documents :
21151547 - Cardiovascular outcomes in patients with normal and abnormal 24-hour ambulatory blood p...
15213737 - Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects.
6722027 - Autonomic function in cholinergic urticaria and atopic eczema.
10869917 - Effect of xenon on autonomic cardiovascular control--comparison with isoflurane and nit...
15338197 - Hemodynamic assessment of splenomegaly in beta-thalassemia patients undergoing splenect...
1892147 - Elevated cerebrospinal fluid pressures in patients with cryptococcal meningitis and acq...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  103     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-31     Completed Date:  2002-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Division of Medical Sciences, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, U.K. h.routledge@bham.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Baroreflex
Blood Pressure / physiology
Blood Pressure Determination
Drinking / physiology*
Electrocardiography
Female
Heart / innervation*
Heart Rate / physiology
Heart Transplantation
Humans
Male
Middle Aged
Signal Processing, Computer-Assisted
Sympathetic Nervous System / physiology
Vagus Nerve / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-term angiotensin-converting enzyme inhibition with ramipril reduces thrombin generation in huma...
Next Document:  Effect of lowering tumour necrosis factor-alpha on vascular endothelial function in Type II diabetes...