Document Detail


Cardiac tumors: the experience of a tertiary cardiology center.
MedLine Citation:
PMID:  18767408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac tumors represent a rare condition, often presenting with severe symptoms and having a poor outcome in the absence of early diagnosis and therapy. The aim of this study was to assess the prevalence and type of cardiac tumors, the techniques used for the diagnosis and the therapy used in a tertiary cardiology center. METHODS: During a 2-years period, among the 35004 patients (pts) hospitalized in our Cardiology Department, 24 pts were diagnosed with CTum (0.068% of all hospitalizations). A retrospective study of CTum cases was based on the patient files, with full clinical data, paraclinic investigations and therapy details. RESULTS: In the CTum group (49 +/- 16.2 years, similar between men and women), the main symptoms leading to patients referral were dyspnea (15 pts, 62.5%) and embolic events (coronary, cerebral, peripheral arteries: 7 pts, 29%), while in 4 asymptomatic pts the diagnosis was incidental. Transthoracic echocardiography (TTE) detected the presence of CTum in all cases. In 20 pts (83%), TTE and transesophageal echocardiography (TEE) provided all the data required for preoperative assessment (tumor size, extension, location, insertion site). In 4 pts, additional CT and MRI investigations were necessary, mainly for complex disease (malignant secondary CTum). The imaging techniques suggested a diagnosis of benign tumor in 15 pts (62.5%) and malignant tumor in 5 pts. In 4 pts the tumor type could not be established. Myxoma was the most frequent diagnosis (14 pts, 58% CTum). Among malignant CTum, secondary tumors (melanoma, lung and uterine cancer) were more frequent than primary CTum (4 vs 1 pt). The localization of CTum was intracavitary in 22 pts, 91% mainly in the left atrium (15 pts), intramyocardic in 1 pt and pericardic in 1 pt. Surgery was performed in 18 pts, confirming the preoperative diagnosis in 17 cases (94%). In one case, a myxochondrosarcoma was diagnosed at pathology in a patient with an echocardiography-based preoperative diagnosis of myxoma. CONCLUSIONS: CTum represent a rare condition, accounting for only 0.068% of hospitalizations in a tertiary cardiology center, but with severe clinical presentation. Echocardiography (TTE and TEE) is the essential imaging modality, allowing in most cases the diagnosis, classification and localization of CTum and their insertion site. CT and MRI are useful additional modalities in complex cases (mainly malignant primary and secondary CTum). In the case of benign tumors, surgery must be performed as soon as possible after the diagnosis has been established, whereas for malignant tumors there is still much controversy in what regards the benefits of surgery.
Authors:
S Giuşcă; Ruxandra Jurcuţ; Marinela Serban; B A Popescu; E Apetrei; Carmen Ginghină
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  45     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:  2007  
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  333-9     Citation Subset:  IM    
Affiliation:
"Prof. C.C. Iliescu" Institute of Cardiovascular Diseases, Bucharest, Romania.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Echocardiography, Transesophageal*
Female
Heart Neoplasms / surgery,  ultrasonography*
Humans
Male
Middle Aged
Retrospective Studies
Romania

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