Document Detail


Cardiac troponins in canine babesiosis.
MedLine Citation:
PMID:  11822806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compared the sensitivity of ECG and cardiac troponins to predict cardiac histopathological changes, clinical severity, and survival in canine babesiosis. One control group (n = 9) and 4 groups of dogs with mild uncomplicated babesiosis (n = 8), severe uncomplicated babesiosis (n = 9), complicated babesiosis (n = 8), and babesiosis and concurrent immune-mediated hemolytic anemia (IMHA) (n = 9) were studied. A 1-minute lead II ECG was recorded, and cardiac troponin I (cTnI) and T (cTnT) concentrations in plasma were measured. cTnI concentrations were significantly higher in the complicated (mean, 9.9; SE, +/-5.76) and concurrent IMHA (mean, 6.53; SE, +/-4.32) groups and in the 3 dogs that died of the disease (mean, 22.17; SE, +/-12.85) than in the control dogs (concentration below detection limit of test, -0.3 ng/mL). The 3 nonsurvivors had the most severe cardiac histopathological changes, but no arrhythmia and minimal other ECG changes. Dogs with babesiosis developed a variety of ECG abnormalities, but the abnormalities were not associated with disease severity, outcome, or plasma cardiac troponin concentrations. The exception was the presence of ventricular premature complexes (VPCs), which were associated with high cardiac troponin concentrations. This study showed an association between cTnI concentration and histological changes, clinical severity, and survival and no correlation between ECG abnormalities and histological changes or biochemical evidence of myocardial damage as reflected by cTnI concentrations. From this study, it was concluded that the analysis of plasma cTnI is a feasible and sensitive test and is superior to cTnT in diagnosing cardiac involvement in dogs with babesiosis.
Authors:
Remo Lobetti; Eran Dvir; Joyce Pearson
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  16     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-02-01     Completed Date:  2002-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
Affiliation:
Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, South Africa. rlobetti@mweb.co.za
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MeSH Terms
Descriptor/Qualifier:
Animals
Babesiosis / mortality,  pathology,  veterinary*
Dog Diseases / mortality*,  pathology*
Dogs
Electrocardiography / veterinary
Female
Male
Predictive Value of Tests
Sensitivity and Specificity
Severity of Illness Index
Survival Analysis
Troponin I / blood*
Troponin T / blood*
Chemical
Reg. No./Substance:
0/Troponin I; 0/Troponin T

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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