Document Detail

Cardiac troponin I release in non-ischemic reversible myocardial injury from parvovirus B19 myocarditis.
MedLine Citation:
PMID:  17010458     Owner:  NLM     Status:  MEDLINE    
Cardiac troponin I is released from myocytes in both reversible and irreversible myocardial injury. The changes in myocyte membrane permeability resulting from the injury could be enough for the release of cardiac troponins from the free cytosolic pool of myocytes without structural damage. We report a case of parvovirus B19 myocarditis in a 26-year-old male who developed regional wall motion abnormalities and severe left ventricular systolic dysfunction with elevated serum levels of cardiac troponin I (peak=11.7 ng/ml). Diagnosis of parvovirus myocarditis was confirmed by presence of high titers of parvovirus B19 IgG and identification of parvovirus B19 DNA by polymerase chain reaction. Within a few days of supportive treatment, the regional wall motion abnormalities resolved, the cardiac function recovered, and the elevation in serum cardiac troponin I subsided. This case further denotes the possibility of release of cardiac troponin I in non-ischemic, reversible myocardial injury.
Muhammad A Baig; Shaukat Ali; Mutahir U Khan; Javeria Rasheed; Abdul Qadir; Balendu C Vasavada; Ijaz A Khan
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Publication Detail:
Type:  Case Reports; Letter     Date:  2006-09-28
Journal Detail:
Title:  International journal of cardiology     Volume:  113     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-13     Completed Date:  2007-01-25     Revised Date:  2007-02-22    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  E109-10     Citation Subset:  IM    
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MeSH Terms
Myocarditis / complications,  metabolism*,  virology*
Parvoviridae Infections / complications,  metabolism*
Parvovirus B19, Human*
Troponin I / secretion*
Reg. No./Substance:
0/Troponin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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