Document Detail


Cardiac troponin I: a potential marker of exercise intolerance in patients with moderate heart failure.
MedLine Citation:
PMID:  12177656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In severe heart failure, increased values of cardiac troponins have been detected during decompensation. In this study, we investigated whether an increase of cardiac troponin I can be observed after symptom-limited exercise and after an exercise training session in patients with moderate heart failure. METHODS: Twenty-seven patients with moderate heart failure (New York Heart Association II-III, ejection fraction 31% +/- 8%) were compared with 9 patients with mild heart failure and 10 subjects without heart failure. They underwent a symptom-limited exercise test and a bicycle exercise training session at >80% of maximal heart rate over 20 to 30 minutes. Plasma cTnI levels were measured at baseline, after symptom-limited exercise (hourly for 5 hours), and after training (4 and 10 hours). RESULTS: Patients with moderate heart failure showed an increase of cTnI from 37 +/- 49 pg/mL to 73 +/- 59 pg/mL (P <.001) after symptom-limited exercise. Four patients with moderate and 1 with mild heart failure and normal cTnI values at rest showed an increase of cTnI above 100 pg/mL after acute exercise but not after training. Subjects without heart failure had lower cTnI levels at rest and significantly lower values after symptom-limited exercise and training (P <.05 for each). CONCLUSION: Patients with symptomatic heart failure reveal an increase of cTnI after symptom-limited exercise at levels that indicate minor myocardial damage. The prognostic impact of this finding should, therefore, be further investigated.
Authors:
Olaf Schulz; Ariane Kromer
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  144     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-14     Completed Date:  2002-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-8     Citation Subset:  AIM; IM    
Affiliation:
Heinrich-Mann-Hospital for Cardiac Rehabilitation, Bad Liebenstein, and the Cooperative Interventional Cardiology Spandau, Berlin, Germany. oschulz@cath-lab-spandau.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Exercise Test
Exercise Tolerance*
Female
Heart Failure / blood*,  diagnosis
Humans
Male
Middle Aged
Troponin I / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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