| Cardiac troponin I: a potential marker of exercise intolerance in patients with moderate heart failure. | |
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MedLine Citation:
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PMID: 12177656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In severe heart failure, increased values of cardiac troponins have been detected during decompensation. In this study, we investigated whether an increase of cardiac troponin I can be observed after symptom-limited exercise and after an exercise training session in patients with moderate heart failure. METHODS: Twenty-seven patients with moderate heart failure (New York Heart Association II-III, ejection fraction 31% +/- 8%) were compared with 9 patients with mild heart failure and 10 subjects without heart failure. They underwent a symptom-limited exercise test and a bicycle exercise training session at >80% of maximal heart rate over 20 to 30 minutes. Plasma cTnI levels were measured at baseline, after symptom-limited exercise (hourly for 5 hours), and after training (4 and 10 hours). RESULTS: Patients with moderate heart failure showed an increase of cTnI from 37 +/- 49 pg/mL to 73 +/- 59 pg/mL (P <.001) after symptom-limited exercise. Four patients with moderate and 1 with mild heart failure and normal cTnI values at rest showed an increase of cTnI above 100 pg/mL after acute exercise but not after training. Subjects without heart failure had lower cTnI levels at rest and significantly lower values after symptom-limited exercise and training (P <.05 for each). CONCLUSION: Patients with symptomatic heart failure reveal an increase of cTnI after symptom-limited exercise at levels that indicate minor myocardial damage. The prognostic impact of this finding should, therefore, be further investigated. |
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Authors:
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Olaf Schulz; Ariane Kromer |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 144 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-14 Completed Date: 2002-09-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 351-8 Citation Subset: AIM; IM |
Affiliation:
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Heinrich-Mann-Hospital for Cardiac Rehabilitation, Bad Liebenstein, and the Cooperative Interventional Cardiology Spandau, Berlin, Germany. oschulz@cath-lab-spandau.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Exercise Test Exercise Tolerance* Female Heart Failure / blood*, diagnosis Humans Male Middle Aged Troponin I / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Troponin I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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