Document Detail

Cardiac troponin increases among runners in the Boston Marathon.
MedLine Citation:
PMID:  17145114     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: Studies indicate that running a marathon can be associated with increases in serum cardiac troponin levels. The clinical significance of such increases remains unclear. We seek to determine the prevalence of troponin increases and epidemiologic factors associated with these increases in a large and heterogeneous cohort of marathon finishers. METHODS: Entrants in the 2002 Boston Marathon were recruited 1 to 2 days before the race. Data collected included demographic and training history, symptoms experienced during the run, and postrace troponin T and I levels. Simple descriptive statistics were performed to describe the prevalence of troponin increases and runner characteristics. RESULTS: Of 766 runners enrolled, 482 had blood analyzed at the finish line. In all, 34% were women, 20% were younger than 30 years, and 92% had run at least 1 previous marathon. Most runners (68%) had some degree of postrace troponin increase (troponin T > or = 0.01 ng/mL or troponin I > or = 0.1 ng/mL), and 55 (11%) had significant increases (troponin T > or = 0.075 ng/mL or troponin I > or = 0.5 ng/mL). Running inexperience (< 5 previous marathons) and young age (< 30 years) were associated with elevated troponins. These correlates were robust throughout a wide range of troponin thresholds considered. Health factors, family history, training, race performance, and symptoms were not associated with increases. CONCLUSION: Troponin increases were relatively common among marathon finishers and can reach levels typically diagnostic for acute myocardial infarction. Less marathon experience and younger age appeared to be associated with troponin increases, whereas race duration and the presence of traditional cardiovascular risk factors were not. Further work is needed to determine the clinical significance of these findings.
Elizabeth B Fortescue; Andrew Y Shin; David S Greenes; Rebekah C Mannix; Suneet Agarwal; Brian J Feldman; Manish I Shah; Nader Rifai; Michael J Landzberg; Jane W Newburger; Christopher S D Almond
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-12-04
Journal Detail:
Title:  Annals of emergency medicine     Volume:  49     ISSN:  1097-6760     ISO Abbreviation:  Ann Emerg Med     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-22     Completed Date:  2007-02-01     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-43, 143.e1     Citation Subset:  AIM; IM    
Department of Cardiology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Troponin / blood*
Grant Support
Reg. No./Substance:

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