Document Detail


Cardiac troponin I in pastured and race-training Thoroughbred horses.
MedLine Citation:
PMID:  12892316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac troponin I (cTnI), a myocardial polypeptide, is a highly sensitive and specific biomarker of myocardial injury in people and dogs. The structure of cTnI is highly conserved across species, and equine myocardium has high reactivity with human immunoassays. The purpose of this study was to describe cTnI concentrations in normal pastured and race-training Thoroughbred horses. Ten horses on pasture and 10 horses in race training were studied. Horses were considered normal on the basis of physical examination, training performance, electrocardiography (ECG), and echocardiography. Serum cTnI concentrations were determined with a colorimetric immunoassay. The assay has an analytical sensitivity of 0.04 ng/mL. Serum cTnI concentrations in race-training horses were not significantly different from those of pastured horses. When groups were combined, mean cTnI concentration (+/- SD) was 0.047 +/- 0.085 ng/mL. and the median was 0 (range, 0-0.35 ng/mL). The 90th percentile for both groups combined was 0.11 ng/mL. This study establishes a preliminary reference range for serum cTnI in normal Thoroughbred horses.
Authors:
Wade Phillips; Steeve Giguère; Robert P Franklin; Jorge Hernandez; Darcy Adin; John G Peloso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  17     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-08-01     Completed Date:  2003-09-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  597-9     Citation Subset:  IM    
Affiliation:
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
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MeSH Terms
Descriptor/Qualifier:
Animal Husbandry
Animals
Breeding
Female
Horses / blood*
Male
Physical Conditioning, Animal*
Physical Endurance
Reference Values
Running
Troponin I / blood*
Chemical
Reg. No./Substance:
0/Troponin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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