Document Detail


Cardiac troponin I: evaluation I of a biomarker for the diagnosis of heart disease in the dog.
MedLine Citation:
PMID:  15789809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To assess the value of measuring blood levels of the myocardial protein cardiac troponin I (cTnl) in the diagnosis of congenital and acquired heart disease in the dog and in the evaluation of the severity of heart failure. METHODS: Serum samples obtained from healthy dogs (n = 26) and from dogs diagnosed with a variety of congenital and acquired heart conditions (n = 35) were assayed for cTnl concentration using an automated immunoassay method. Results were also analysed according to the degree of heart failure as assessed using the International Small Animal Cardiac Health Council's scheme. RESULTS: Healthy dogs had very low or undetectable blood cTnl levels, as did dogs with congenital heart disease. However, cTnl levels were significantly elevated in dogs with acquired mitral valve disease, dilated cardiomyopathy and pericardial effusion. Blood cTnl levels also varied with severity of heart failure. CLINICAL SIGNIFICANCE: Measurement of blood cTnl levels may be a useful aid in the diagnosis of dogs with suspected heart disease and in indicating the severity of heart failure.
Authors:
D P Spratt; R J Mellanby; N Drury; J Archer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of small animal practice     Volume:  46     ISSN:  0022-4510     ISO Abbreviation:  J Small Anim Pract     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-25     Completed Date:  2005-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0165053     Medline TA:  J Small Anim Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Affiliation:
Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / blood
Case-Control Studies
Dog Diseases / blood*,  diagnosis
Dogs
Female
Heart Diseases / blood,  diagnosis,  veterinary*
Immunoassay / methods,  veterinary
Male
ROC Curve
Sensitivity and Specificity
Severity of Illness Index
Troponin I / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin I
Comments/Corrections
Comment In:
J Small Anim Pract. 2005 Mar;46(3):113-4   [PMID:  15789805 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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