| Cardiac troponin elevations in chronic renal failure: prevalence and clinical significance. | |
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MedLine Citation:
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PMID: 10211629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of the study was investigate the prevalence of abnormal values of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in patients with chronic renal failure (CRF) and their clinical significance. DESIGN AND METHODS: We investigated the concentrations of cTnT and cTnI in 49 CRF patients without heart disease or diabetes. Cardiac TnT values were measured with a second generation immunoassay and cTnI with two immunoassays with different analytical sensitivity. All CRF patients underwent regular clinical follow-up over a 18-month period. RESULTS: No patients with CRF had elevated values of cTnI when measured with one assay and only 2 patients displayed minimally elevated values with the second assay. In contrast, 23 CRF patients (47%) displayed cTnT concentrations elevated above the upper reference limit. The elevated cTnT values observed were below the values detected in acute myocardial infarction and were not associated with adverse cardiac events during follow-up. CONCLUSIONS: Mildly elevated cTnT concentrations are common in patients with CRF and do not appear to be associated with adverse coronary events. |
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Authors:
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P Musso; I Cox; E Vidano; D Zambon; M Panteghini |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical biochemistry Volume: 32 ISSN: 0009-9120 ISO Abbreviation: Clin. Biochem. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-05-25 Completed Date: 1999-05-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 125-30 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Ospedale Civile, Ivrea, Italy. mussop@ivrea.alpcom.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / blood Creatine Kinase / blood Female Humans Immunoassay / methods Kidney Failure, Chronic / metabolism*, therapy* Kidney Transplantation Male Middle Aged Myocardium / metabolism* Myoglobin / analysis Predictive Value of Tests Renal Replacement Therapy Sensitivity and Specificity Troponin I / blood* Troponin T / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Myoglobin; 0/Troponin I; 0/Troponin T; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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