Document Detail

Cardiac troponin elevations in chronic renal failure: prevalence and clinical significance.
MedLine Citation:
PMID:  10211629     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of the study was investigate the prevalence of abnormal values of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in patients with chronic renal failure (CRF) and their clinical significance. DESIGN AND METHODS: We investigated the concentrations of cTnT and cTnI in 49 CRF patients without heart disease or diabetes. Cardiac TnT values were measured with a second generation immunoassay and cTnI with two immunoassays with different analytical sensitivity. All CRF patients underwent regular clinical follow-up over a 18-month period. RESULTS: No patients with CRF had elevated values of cTnI when measured with one assay and only 2 patients displayed minimally elevated values with the second assay. In contrast, 23 CRF patients (47%) displayed cTnT concentrations elevated above the upper reference limit. The elevated cTnT values observed were below the values detected in acute myocardial infarction and were not associated with adverse cardiac events during follow-up. CONCLUSIONS: Mildly elevated cTnT concentrations are common in patients with CRF and do not appear to be associated with adverse coronary events.
P Musso; I Cox; E Vidano; D Zambon; M Panteghini
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical biochemistry     Volume:  32     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-05-25     Completed Date:  1999-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Department of Cardiology, Ospedale Civile, Ivrea, Italy.
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MeSH Terms
Biological Markers / blood
Creatine Kinase / blood
Immunoassay / methods
Kidney Failure, Chronic / metabolism*,  therapy*
Kidney Transplantation
Middle Aged
Myocardium / metabolism*
Myoglobin / analysis
Predictive Value of Tests
Renal Replacement Therapy
Sensitivity and Specificity
Troponin I / blood*
Troponin T / blood*
Reg. No./Substance:
0/Biological Markers; 0/Myoglobin; 0/Troponin I; 0/Troponin T; EC Kinase

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