| Cardiac troponin I concentrations in neonates with hypoxic-ischaemic encephalopathy. | |
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MedLine Citation:
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PMID: 21801203 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Myocardial dysfunction is a frequent sequel of perinatal asphyxia. Cardiac troponin I (cTnI) is a marker of myocardial injury and a surrogate marker of myocardial dysfunction in adults, but there are few data in neonates. Aim: To compare serum cTnI concentrations with clinical severity of encephalopathy and with duration of inotropic support in asphyxiated neonates. Methods: Retrospective study of 60 neonates admitted with hypoxic-ischaemic encephalopathy (HIE). CTnI concentrations measured within 36 h of birth were compared with clinical grade of HIE (Sarnat-Sarnat classification) and with duration of inotropic support. Results: Serum cTnI concentrations and duration of inotropic support were significantly greater with increasing severity of HIE. Median (95% CI) cTnI concentrations were: 0.04 μg/L (0.02--0.07 μg/L) in grade 1 HIE, 0.12 μg/L (0.08--0.20 μg/L) in grade 2 HIE, and 0.67 μg/L (0.41--1.35 μg/L) in grade 3 HIE. Median (95% CI) duration of inotropic support required was: 0 h (0--24 h) in grade 1 HIE, 28 h (0--118 h) in grade 2 HIE, and 48 h (0--140 h) in grade 3 HIE. Conclusion: In asphyxiated neonates, cardiac troponin I concentrations within 36 h of birth correlate strongly with clinical grade of HIE and with duration of inotropic support. Early cardiac troponin I concentrations may provide a useful proxy marker for the anticipated severity of myocardial dysfunction. |
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Authors:
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Aravind T Shastri; Sujeevan Samarasekara; Hemananda Muniraman; Paul Clarke |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-29 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Acta Paediatrica © 2011 Foundation Acta Paediatrica. |
Affiliation:
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Neonatal Unit, Norfolk & Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich, Norfolk. NR4 7UY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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