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Cardiac troponin I concentrations in neonates with hypoxic-ischaemic encephalopathy.
MedLine Citation:
PMID:  21801203     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Myocardial dysfunction is a frequent sequel of perinatal asphyxia. Cardiac troponin I (cTnI) is a marker of myocardial injury and a surrogate marker of myocardial dysfunction in adults, but there are few data in neonates. Aim:  To compare serum cTnI concentrations with clinical severity of encephalopathy and with duration of inotropic support in asphyxiated neonates. Methods:  Retrospective study of 60 neonates admitted with hypoxic-ischaemic encephalopathy (HIE). CTnI concentrations measured within 36 h of birth were compared with clinical grade of HIE (Sarnat-Sarnat classification) and with duration of inotropic support. Results:  Serum cTnI concentrations and duration of inotropic support were significantly greater with increasing severity of HIE. Median (95% CI) cTnI concentrations were: 0.04 μg/L (0.02--0.07 μg/L) in grade 1 HIE, 0.12 μg/L (0.08--0.20 μg/L) in grade 2 HIE, and 0.67 μg/L (0.41--1.35 μg/L) in grade 3 HIE. Median (95% CI) duration of inotropic support required was: 0 h (0--24 h) in grade 1 HIE, 28 h (0--118 h) in grade 2 HIE, and 48 h (0--140 h) in grade 3 HIE. Conclusion:  In asphyxiated neonates, cardiac troponin I concentrations within 36 h of birth correlate strongly with clinical grade of HIE and with duration of inotropic support. Early cardiac troponin I concentrations may provide a useful proxy marker for the anticipated severity of myocardial dysfunction.
Authors:
Aravind T Shastri; Sujeevan Samarasekara; Hemananda Muniraman; Paul Clarke
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-29
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Acta Paediatrica © 2011 Foundation Acta Paediatrica.
Affiliation:
Neonatal Unit, Norfolk & Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich, Norfolk. NR4 7UY.
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