Document Detail

Cardiac troponin-I concentrations in dogs with bradyarrhythmias before and after artificial pacing.
MedLine Citation:
PMID:  21030328     Owner:  NLM     Status:  In-Process    
OBJECTIVES: To quantify cardiac troponin-I (cTnI) concentration in dogs with symptomatic bradyarrhythmias before and after artificial pacing and to correlate cTnI concentration with diagnosis, echocardiographic parameters, serology, and outcome.
ANIMALS, MATERIALS AND METHODS: Medical records from the University of Pennsylvania from 2006 to 2009 were reviewed, and 14 dogs with cTnI assay results before and after pacemaker were identified. The ECG diagnosis included complete atrioventricular block (AVB), sick sinus syndrome, 2nd degree AVB, and atrial standstill. Serology, presence of premature beats, echocardiographic measurements, and pacing modality were recorded.
RESULTS: Mean cTnI concentration was elevated both pre- and post-pacing, and was significantly higher pre-pacing vs. post-pacing. Post-pacing cTnI concentration in 9 of 14 dogs (64%) remained above the reference range. Four dogs yielded high serum titers for Bartonella spp. Four dogs with markedly increased cTnI concentration had progressive left ventricular enlargement and myocardial failure as compared to pre-pacing examination.
CONCLUSIONS: Elevated cTnI concentration suggests that cardiac injury persists after artificial pacing in dogs with bradyarrhythmias. Myocarditis secondary to Bartonella spp. or other causes may be an important cause of AVB in dogs. Prospective studies investigating the correlation of cTnI to potential etiology and development of post-pacing LV dysfunction and outcome are needed.
Dennis J Trafny; Mark A Oyama; Chloe Wormser; Caryn A Reynolds; Gretchen E Singletary; Gordon D Peddle
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Publication Detail:
Type:  Journal Article     Date:  2010-10-28
Journal Detail:
Title:  Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology     Volume:  12     ISSN:  1875-0834     ISO Abbreviation:  J Vet Cardiol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101163270     Medline TA:  J Vet Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  183-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, MJR-VHUP-Cardiology, 3900 Delancey St., Philadelphia, PA 19104, United States.
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