Document Detail

Cardiac troponin I concentrations following medetomidine-butorphanol sedation in dogs.
MedLine Citation:
PMID:  20636565     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of medetomidine-butorphanol sedation on serum cardiac troponin I (cTnI) concentration, a marker of myocardial ischemia and injury, in healthy dogs undergoing pre-surgical radiographs for orthopedic procedures. STUDY DESIGN: Prospective clinical study. ANIMALS: Twenty client-owned dogs with no history of cardiac disease. METHODS: Dogs were evaluated for pre-existing cardiac disease with electrocardiogram (ECG), noninvasive blood pressure and echocardiogram. Sedation was achieved using a combination of medetomidine (10 microg kg(-1)) and butorphanol (0.2 mg kg(-1)) intravenously. Blood pressure, heart rate and ECG were serially recorded throughout the duration of sedation. Serum cTnI concentration was measured at baseline and 6, 18, and 24-hours post-sedation. RESULTS: Following administration of medetomidine and butorphanol, all dogs were adequately sedated for radiographs and had a decreased heart rate and increased diastolic blood pressure. Arrhythmias associated with increased parasympathetic tone occurred, including a sinus arrhythmia further characterized as a sinus bigeminy in 17 of the dogs. Serum cTnI was undetectable at all time points in all but three dogs. Two of the three dogs had a detectable concentration of cTnI at all time points measured, including prior to sedation. Only one of the two dogs had a cTnI concentration above the normal reference interval. The dogs that exhibited detectable cTnI had no significant difference in signalment, heart rate, blood pressure, or lactate concentration as compared to those with undetectable cTnI. CONCLUSIONS AND CLINICAL RELEVANCE: Sedation with medetomidine and butorphanol had predictable cardiovascular effects including bradycardia, an increase in arterial blood pressure, and arrhythmias in apparently healthy dogs requiring radiographs for orthopedic injuries, but did not induce significant increases in serum cTnI concentration following the drug doses used in this study.
Gretchen E Singletary; Ashley B Saunders; W Brian Saunders; Jan S Suchodolski; Jörg M Steiner; Geoffery T Fosgate; Sandee M Hartsfield
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  37     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  342-6     Citation Subset:  IM    
Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA.
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MeSH Terms
Blood Pressure / drug effects
Butorphanol / administration & dosage,  pharmacology*
Drug Therapy, Combination / veterinary
Echocardiography / veterinary
Electrocardiography / veterinary
Heart Rate / drug effects
Hypnotics and Sedatives / pharmacology*
Injections, Intravenous / veterinary
Medetomidine / administration & dosage,  pharmacology*
Time Factors
Troponin I / blood*
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Troponin I; 42408-82-2/Butorphanol; 86347-14-0/Medetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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