Document Detail


Cardiac troponin I after cardiopulmonary bypass in infants in comparison with older children.
MedLine Citation:
PMID:  22814215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: At the present time, there is a trend towards performing open heart surgery at a younger age. Myocardium of infants has been thought to be more vulnerable to cardiopulmonary bypass in comparison with adults. For this study, we evaluated the degree of myocardial injury by measurement of cardiac troponin levels in infants in comparison with older children for similar surgeries.
METHODS: Serum was collected before bypass, after bypass, and daily after surgery and serum cardiac troponin I level (micrograms per litre). The demographic data, cardiac diagnoses, types of surgery performed, and peri-operative parameters were collected.
RESULTS: Of the 21 children enrolled consecutively, five were infants. Among the 21 patients, four patients had post-operative peak troponin values greater than 100 (three were infants) and all four patients survived and had normal left ventricular systolic function upon discharge echocardiogram. The five infants had peak troponin levels of 222.3, 202, 129, 26.7, and 82.3. The post-operative peak troponin levels were significantly higher in infants (mean 132.5 with a standard deviation of 81.6) than in the older children (mean 40.3 with a standard deviation of 33.4), although there was no significant difference in bypass time, bypass temperature, cross-clamp time, or the length of stay in the intensive care unit between the two age groups.
CONCLUSIONS: Higher troponin release is seen in infants in comparison with older children after bypass for similar surgeries. A troponin level greater than 100 after bypass does not necessarily predict death or a severe cardiovascular event in the very young.
Authors:
Monesha Gupta-Malhotra; Jeffrey H Kern; Patrick A Flynn; Myles S Schiller; Jan M Quaegebeur; Deborah M Friedman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-20
Journal Detail:
Title:  Cardiology in the young     Volume:  23     ISSN:  1467-1107     ISO Abbreviation:  Cardiol Young     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-07     Completed Date:  2014-01-09     Revised Date:  2014-02-26    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Cardiopulmonary Bypass*
Child
Child, Preschool
Female
Humans
Infant
Length of Stay / statistics & numerical data
Male
Postoperative Complications
Prospective Studies
Time Factors
Troponin I / blood*
Grant Support
ID/Acronym/Agency:
5K23HL089301-03/HL/NHLBI NIH HHS; K23 HL089391/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin I
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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