Document Detail

Cardiac troponin T release and inflammation demonstrated in marathon runners.
MedLine Citation:
PMID:  20380359     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: As shown on the basis of highly sensitive assays, cardiac troponin release is now observed after physiological heart stress and in mild heart pathologies: both are [corrected] considered unrelated to the irreversible cardiac alteration that is typically the source of release. Transitory cardiac membrane leakage was suggested as the basis. In our view, mild inflammation may drive this type of cardiac troponin release. To verify this hypothesis, marathon runners who demonstrated post-run inflammation were used as a model to correlate cTnT release and inflammation intensity.
METHODS: In 78 male marathon runners who participated in the BERLIN-MARATHON 2006, cardiac troponin T (cTnT) was monitored [corrected] at three time points (pre-race, post-race, and after two weeks of rest). [corrected] Measurements were done with the highly sensitive assay (hs cTnT assay) and the conventional fourth-generation cTnT assay for comparison. Concurrently, [corrected] the inflammation markers (leukocyte and neutrophil counts, CRP, IL-6) were measured.
RESULTS: Pre-race, the fourth-generation assay failed to demonstrate cTnT positivity (> test specific LLD). In contrast, with the [corrected] use of the highly sensitive assay, 28% of the participants were positive for cTnT (> LLD of hs cTnT assay). Post-race, cTnT as measured with the fourth-generation assay was observed to be detectable in 43% of the runners (> LLD = 99(th) percentile cut off), but all runners had detectable cTnT values (> LLD) when measured with the highly sensitive assay. Even in 94% of these cTnT-positive runners, the value exceeded the 99(th) percentile cut off determined for the highly sensitive assay (13 ng/L). cTnT release correlated significantly with inflammation intensity. Faster runners demonstrated significantly stronger cTnT releases and inflammation signs.
CONCLUSIONS: As demonstrated after physiological heart stress such as marathon running, transitory inflammation is evidently one of the events contributing to the cardiac troponin release under conditions suggested as unrelated to irreversible cardiac alteration.
Silvia Gilka Munzoz Saravia; Fabian Knebel; Sabrina Schroeckh; Reinhard Ziebig; Andreas Lun; Andreas Weimann; Annekathrin Haberland; Adrian C Borges; Ingolf Schimke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical laboratory     Volume:  56     ISSN:  1433-6510     ISO Abbreviation:  Clin. Lab.     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-04-30     Revised Date:  2011-04-21    
Medline Journal Info:
Nlm Unique ID:  9705611     Medline TA:  Clin Lab     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  51-8     Citation Subset:  IM    
Medizinische Klinik (Kardiologie), Charité--Universitätsmedizin Berlin, Berlin, Germany.
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MeSH Terms
Asthma / blood,  epidemiology
Athletic Injuries / blood*
Blood Pressure
Heart Rate
Hypertension / blood,  epidemiology
Inflammation / blood,  etiology*
Running / physiology*
Sensitivity and Specificity
Troponin T / blood*
Reg. No./Substance:
0/Troponin T
Erratum In:
Clin Lab. 2011;57(3-4):273

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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