Document Detail


Cardiac troponin T as a marker of myocardial injury in a group of asphyxiated African neonates.
MedLine Citation:
PMID:  22525447     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: In caucasian newborns, troponin T (cTnT) is a specific marker for myocardial injury in perinatal asphyxia. This is the first such study in negroid neonates.
AIMS: To evaluate myocardial injury in a group of asphyxiated African newborns and determine the influence of mode of delivery on cTnT levels.
METHODS: Serum cTnT and clinical parameters in 40 asphyxiated and 40 healthy negroid neonatal controls were measured within the first 72 hours of life by chemiluminescence immune-assay. Perinatal asphyxia was assessed by APGAR score. The infants were followed up until discharge or death.
RESULTS: Mean (SD) cTnT values were significantly higher in asphyxiated infants [0·03 (0·04) ng/ml] than in healthy controls [0·01 (0·006) ng/ml, P = 0·002]. Asphyxiated infants delivered by forceps and vacuum extraction had significantly higher levels of cTnT [0·04 (0·018) ng/ml] than those born by caesarian section [0·02 (0·008) ng/ml] and by normal delivery [0·03 (0·01) ng/ml, P = 0·003]. cTnT levels were higher in infants who died (P = 0·037).
CONCLUSION: In the asphyxiated infants, mean cTnT levels were significantly higher than in controls. They were also significantly higher in those born by vacuum and forceps delivery and asphyxiated infants who died.
Authors:
W E Sadoh; C O Eregie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatrics and international child health     Volume:  32     ISSN:  2046-9055     ISO Abbreviation:  Paediatr Int Child Health     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101582666     Medline TA:  Paediatr Int Child Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Affiliation:
Department of Child Health, University of Benin, Nigeria.
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