Document Detail

Cardiac troponin T as a marker of myocardial injury in a group of asphyxiated African neonates.
MedLine Citation:
PMID:  22525447     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: In caucasian newborns, troponin T (cTnT) is a specific marker for myocardial injury in perinatal asphyxia. This is the first such study in negroid neonates.
AIMS: To evaluate myocardial injury in a group of asphyxiated African newborns and determine the influence of mode of delivery on cTnT levels.
METHODS: Serum cTnT and clinical parameters in 40 asphyxiated and 40 healthy negroid neonatal controls were measured within the first 72 hours of life by chemiluminescence immune-assay. Perinatal asphyxia was assessed by APGAR score. The infants were followed up until discharge or death.
RESULTS: Mean (SD) cTnT values were significantly higher in asphyxiated infants [0·03 (0·04) ng/ml] than in healthy controls [0·01 (0·006) ng/ml, P = 0·002]. Asphyxiated infants delivered by forceps and vacuum extraction had significantly higher levels of cTnT [0·04 (0·018) ng/ml] than those born by caesarian section [0·02 (0·008) ng/ml] and by normal delivery [0·03 (0·01) ng/ml, P = 0·003]. cTnT levels were higher in infants who died (P = 0·037).
CONCLUSION: In the asphyxiated infants, mean cTnT levels were significantly higher than in controls. They were also significantly higher in those born by vacuum and forceps delivery and asphyxiated infants who died.
W E Sadoh; C O Eregie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatrics and international child health     Volume:  32     ISSN:  2046-9055     ISO Abbreviation:  Paediatr Int Child Health     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101582666     Medline TA:  Paediatr Int Child Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Department of Child Health, University of Benin, Nigeria.
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