Document Detail

Cardiac troponin I (2nd generation assay) in chronic haemodialysis patients: prevalence and prognostic value.
MedLine Citation:
PMID:  12686669     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Elevated serum cardiac troponin T (cTnT) levels are frequently observed in chronic dialysis patients and have been shown to be associated with increased morbidity and mortality. The aim of this study was to determine whether cardiac troponin I (cTnI), which is less frequently elevated, has similar clinical significance. METHODS: We studied 101 asymptomatic patients with no clinical evidence of coronary artery disease who were undergoing chronic dialytic treatment. We measured their serum cTnI levels immediately before the start of their dialysis sessions by a second-generation assay (OPUS-DADE). Our study included a year-long follow-up with trimestrial cTnI assays as well as clinical, X-ray and echocardiographic surveillance. We considered patients with serum cTnI > or =0.15 ng/ml as positive and those with levels <0.15 ng/ml as negative. RESULTS: Among the 14 patients with high serum cTnI levels, nine (64%) suffered acute cardiac events during the 12-month follow-up. In contrast, among the 72 patients with low cTnI levels only seven (9.7%) had acute events. In another group of 15 patients with variable cTnI levels, three patients (20%) had cardiac events. CONCLUSION: Based on these results, serum cTnI appears to be a valuable predictive marker of cardiovascular events in asymptomatic dialysis patients. For those patients who might benefit from thorough cardiac investigation and treatment, information on cTnI could be useful in preventing cardiac events.
Marta Beciani; Angela Tedesco; Anneo Violante; Silvia Cipriani; Michele Azzarito; Antonio Sturniolo; Giorgio Splendiani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  18     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-10     Completed Date:  2004-01-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  942-6     Citation Subset:  IM    
Chemical Laboratory, Aurelia Hospital, Rome, Italy.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Heart Diseases / blood,  etiology
Kidney Failure, Chronic / blood,  complications,  therapy
Middle Aged
Myocardium / metabolism*
Renal Dialysis*
Risk Factors
Troponin I / blood*
Reg. No./Substance:
0/Biological Markers; 0/Troponin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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